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1.1.1.8: glycerol-3-phosphate dehydrogenase (NAD+)

This is an abbreviated version!
For detailed information about glycerol-3-phosphate dehydrogenase (NAD+), go to the full flat file.

Word Map on EC 1.1.1.8

Reaction

sn-glycerol 3-phosphate
+
acceptor
=
glycerone phosphate
 +
reduced acceptor

Synonyms

(NAD+)-dependent G3pdh, (NAD+)-dependent glycerol-3-phosphate dehydrogenase, 100383152, alpha glycerophosphate dehydrogenase, alpha-glycerol phosphate dehydrogenase (NAD), alpha-glycerophosphate dehydrogenase (NAD), Cagpd1, Cagpd1p, Cagpd2, Cagpd2p, cG3PDH, CgGPD, cGPdH, cytoplasmic NAD-dependent glycerol-3-phosphate dehydrogenase, cytosolic GPDH, dehydrogenase, glycerol phosphate, DhGPD1, G-3-P dehydrogenase, G3P dehydrogenase, G3PD, G3PD1, G3PD2, G3PD3, G3PDH, GDM, GDP2, GLPD, GLY1, glycerol 1-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase, glycerol 3-phosphate dehydrogenase 1, glycerol phosphate dehydrogenase (NAD), glycerol-3-phosphate dehydrogenase, glycerol-3-phosphate dehydrogenase 1, glycerophosphate dehydrogenase (NAD), GPD, GPD1, Gpd1p, gpd2p, GPDH, GPDH-1, GPDH-2, GPDH1, GPDH2, GPDH3, GPDH4, GPDH5, GPDH: NAD+ 2 oxidoreductase, GPDH: NAD+ 2 oxidorreductase, GPDHc1, GRMZM2G090747_T01, GRMZM2G155348_T01, GRMZM2G173195_T01, GRMZM6G161711_T01, hydroglycerophosphate dehydrogenase, L-alpha-glycerol phosphate dehydrogenase, L-alpha-glycerophosphate dehydrogenase, L-glycerol 3-phosphate dehydrogenase, L-glycerol phosphate dehydrogenase, L-glycerophosphate dehydrogenase, mGPDH, NAD+-dependent G3P dehydrogenase, NAD+-dependent glycerol 3-phosphate dehydrogenase, NAD+-dependent glycerol-3-phosphate dehydrogenase, NAD+-GPDH, NAD-alpha-glycerophosphate dehydrogenase, NAD-dependent cG3PDH, NAD-dependent glycerol phosphate dehydrogenase, NAD-dependent glycerol-3-phosphate dehydrogenase, NAD-L-glycerol-3-phosphate dehydrogenase, NAD-linked glycerol 3-phosphate dehydrogenase, NADH-dihydroxyacetone phosphate reductase, NADP+-dependent glycerol 3-phosphate dehydrogenase, SFD1, SFD1/GLY1, ZEAMMB73_Zm00001d010670, ZEAMMB73_Zm00001d041962, ZEAMMB73_Zm00001d042152, ZmGPDH1, ZmGPDH3, ZmGPDH4, ZmGPDH5

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.8 glycerol-3-phosphate dehydrogenase (NAD+)

pH Range

pH Range on EC 1.1.1.8 - glycerol-3-phosphate dehydrogenase (NAD+)

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
10 - 10.5
-
maximal activities of the three allelic forms are obtained within a pH range of 10.0-10.5 for glycerol 3-phosphate oxidation
5 - 7.5
5 - 8.1
-
about half-maximal activity at pH 5.0 and 8.1, reduction of dihydroxyacetone phosphate
5.2 - 7.8
-
about half-maximal activity between pH 5.2 and 7.8, reduction of dihydroxyacetone phosphate
5.8 - 7.2
-
reduction of dihydroxyacetone phosphate occurs over a broad range between 5.8 to 7.2
6 - 6.5
-
maximal activities of the three allelic forms are obtained within a pH range of 6.0-6.5 for dihydroxyacetone phosphate reduction
6.5 - 8.2
-
about half-maximal activity at pH 6.5 and 8.2, reduction of dihydroxyacetone phosphate
6.7 - 8.7
-
about 80% of maximal activity at pH 6.7 and 8.7, reduction of dihydroxyacetone phosphate, decrease of activity below and above these pH values
6.8 - 7.2
-
activity falls off rapidly as pH is increased
7 - 8
-
dihydroxyacetone reduction, activity decreases rapidly below pH 7.0 and above pH 8.0, more rapidly at acidic values
7.5 - 8
-
pH-rate profile for the reduction of dihydroxyacetone phosphate shows rather sharp optimum between pH 7.5 and 8.0
7.9 - 8.2
-
maximum activity in pH interval 7.9-8.2
8 - 10
-
about half-maximal activity at pH 8.0 and 10.0, oxidation of glycerol 3-phosphate, isozymes P-III, liver
8 - 11
-
about half-maximal activity at pH 8.0 and 11.0, oxidation of L-glycerol-3-phosphate
8.1 - 9.4
-
about 80% of maximal activity at pH 8.1 and 9.4, oxidation of glycerol-3-phosphate, decrease of activity below and rapidly above these pH values
8.6 - 10
-
about half-maximal activity at pH 8.6 and 10.0, oxidation of glycerol 3-phosphate
additional information
-
A change in pH from pH 8.0 to pH 7.5 leads to increased G3PDH affinity for NAD+. With a change in pH from pH 8.0 to pH 7.5 at 22°C in the euthermic and hibernator conditions, the Km for NAD+ decreases by 62% and 53%, respectively