1.1.1.64: testosterone 17beta-dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about testosterone 17beta-dehydrogenase (NADP+), go to the full flat file.

Reaction

Synonyms

17-ketoreductase, 17beta-HSD, 17beta-HSD 3, 17beta-HSD type 3, 17beta-HSD type 5, 17beta-HSD-3, 17beta-HSD1, 17beta-HSD3, 17beta-HSD4, 17beta-HSD5, 17beta-hydroxysteroid dehydrogenase, 17beta-hydroxysteroid dehydrogenase 3, 17beta-hydroxysteroid dehydrogenase type 3, 17beta-hydroxysteroid dehydrogenase type 5, 17beta-hydroxysteroid dehydrogenases type 3, 17betaHSD3, 3beta-hydroxysteroid dehydrogenase type 3, AKR1C3, HSD17B3, More, NADP-dependent testosterone-17beta-oxidoreductase, type 3 17beta-HSD, type 3 17beta-hydroxysteroid dehydrogenase, type 5 17beta-hydroxysteroid dehydrogenase, type 5 beta-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.64 testosterone 17beta-dehydrogenase (NADP+)

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Results	in table
1	Activating Compound
24	AA Sequence
5	Application
1	CAS Registry Number
12	Cloned(Commentary)
57	Cofactor
6	Crystallization (Commentary)
31	Disease/ Diagnostics
5	Expression
17	General Information
1	General Stability
114	IC50 Value
231	Inhibitors
1	kcat/KM [mM/s]
12	Ki Value [mM]
31	KM Value [mM]
23	Localization
9	Molecular Weight [Da]
55	Natural Substrates/ Products (Substrates)
65	Organism
7	Pathway
52	PDB ID
12	pH Optimum
2	pH Range
16	Protein Variants
7	Purification (Commentary)
3	Reaction
3	Reaction Type
65	Reference
78	Source Tissue
7	Specific Activity [micromol/min/mg]
2	Storage Stability
112	Substrates and Products (Substrate)
1	Subunits
65	Synonyms
1	Systematic Name
7	Temperature Optimum [°C]
1	Temperature Stability [°C]
1	Turnover Number [1/s]

Cloned

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Cloned on EC 1.1.1.64 - testosterone 17beta-dehydrogenase (NADP+)

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Homo sapiens

-

287223

17beta-hydroxysteroid dehydrogenase 3, expressed in human embryonic kidney 293 cells

Homo sapiens

-

287221

expressed in LNCaP cells and in an 293-EBNA-based cell line

Homo sapiens

-

700187

expression in Escherichia coli

Homo sapiens

P42330

723866

expression in HEK-293 cell

Homo sapiens

P37058

724550, 724850

expression in HeLa cell

Homo sapiens

P37058

724555

expression of AKR1C3 in Eschericha coli

Homo sapiens

-

675981

gene HSD17B3, recombinant expression in HEK-293 cells

Homo sapiens

P37058

740916

HEK-293 cells are transduced to express human HSD17B3. The system is also applicable to detect the conversion of 11-ketoandrostenedione to 11-ketotestosterone by HSD17B3

Homo sapiens

-

761760

LC540 cells stably overexpress the enzyme (17beta-HSD3)

Homo sapiens

P37058

761168

recombinant expression of C-terminally His6-tagged enzyme in Escherichia coli strain BL21(DE3)

Homo sapiens

P42330

739797