1.1.1.52: 3alpha-hydroxycholanate dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about 3alpha-hydroxycholanate dehydrogenase (NAD+), go to the full flat file.
Reaction
Synonyms
alpha-hydroxy-cholanate dehydrogenase, dehydrogenase, 3alpha-hydroxycholanate
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.52 - 3alpha-hydroxycholanate dehydrogenase (NAD+)
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REACTION DIAGRAM
3alpha-hydroxy-bis-norcholanic acid + NAD+
3-oxo-bis-norcholanic acid + NADH
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
3alpha-hydroxy-norcholanic acid + NAD+
3-oxo-norcholanic acid + NADH
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
cholic acid + NAD+
7alpha,12alpha-dihydroxy-3-oxo-5beta-cholan-24-oic acid + NADH
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
dehydrocholic acid + NADH
3-hydroxy-7,12-dihydroxy-5beta-cholan-24-oic acid + NAD+
-
i.e. 3,7,12-trioxocholan-24-oic acid
-
-
r
deoxycholic acid + NAD+
12alpha-hydroxy-3-oxo-5beta-cholan-24-oic acid + NADH + H+
-
oxidation at the same rate as hydroxycholanic acid
-
-
r
additional information
?
-
-
no substrates: androsterone and tetrahydrocortisone, methylation of carboxyl group or reduction to alcohol inactivates
-
-
?
3alpha-hydroxy-5beta-cholanate + NAD+
3-oxo-5beta-cholanate + NADH
-
i.e. lithocholic acid
-
r