1.1.1.44: phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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For detailed information about phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating), go to the full flat file.

Word Map on EC 1.1.1.44

1.1.1.44

glucose-6-phosphate

pentose

acp

gpi

malic

lipogenic

allozymes

pelteobagrus

monomorphic

srebp-1

4.1.3.8

fulvidraco

duffy

physcion

tropica

zymodemes

medicine

synthesis

pharmacology

biotechnology

agriculture

Reaction

Synonyms

6-GPD, 6-P-gluconate dehydrogenase, 6-Pgd, 6-PGDH, 6-PGDHase, 6-phospho-D-gluconate dehydrogenase, 6-phospho-D-gluconate-NADP+ oxidoreductase, decarboxylating, 6-phosphogluconate dehydrogenase, 6-phosphogluconate dehydrogenase (decarboxylating), 6-phosphogluconate dehydrogenase 1, 6-phosphogluconate dehydrogenase Gnd1, 6-phosphogluconate dehydrogenase, decarboxylating, 6-phosphogluconate-dehydrogenase, 6-phosphogluconate:NADP oxidoreductase, 6-phosphogluconic carboxylase, 6-phosphogluconic dehydrogenase, 6-phosphonogluconate dehydrogenase, 6PDH, 6PG DH, 6PGD, 6PGDH, 6PGDH/Gnd1, 6PGDH1, 6PGDH2, 6PGDH3, At1G64190, At3g02360, At5g41670, D-gluconate-6-phosphate dehydrogenase, GCG1, gnd, GND1, Gnd1p, Gnd2p, GNTZII, LlPDH, Moth_1283, Os6PGDH1, Os6PGDH2, p6PGDH, peroxisomal 6-phosphogluconate dehydrogenase, Pgd, PGD1, PGD2, PGD3, phosphogluconic acid dehydrogenase, TM0438, YpjI, zwf3

ECTree

1 Oxidoreductases

1.1 Acting on the CH-OH group of donors

1.1.1 With NAD⁺ or NADP⁺ as acceptor

1.1.1.44 phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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Results	in table
24	Activating Compound
27534	AA Sequence
13	Application
1	CAS Registry Number
37	Cloned(Commentary)
114	Cofactor
31	Crystallization (Commentary)
192	Disease/ Diagnostics
6	Expression
52	General Information
13	General Stability
73	IC50 Value
569	Inhibitors
47	kcat/KM [mM/s]
90	Ki Value [mM]
283	KM Value [mM]
78	Localization
22	Metals/Ions
129	Molecular Weight [Da]
270	Natural Substrates/ Products (Substrates)
6	Organic Solvent Stability
976	Organism
8	Pathway
74	PDB ID
69	pH Optimum
10	pH Range
5	pH Stability
8	pI Value
4	Posttranslational Modification
50	Protein Variants
99	Purification (Commentary)
2	Reaction
4	Reaction Type
331	Reference
216	Source Tissue
66	Specific Activity [micromol/min/mg]
21	Storage Stability
439	Substrates and Products (Substrate)
129	Subunits
223	Synonyms
1	Systematic Name
31	Temperature Optimum [°C]
7	Temperature Range [°C]
26	Temperature Stability [°C]
70	Turnover Number [1/s]

Expression

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Expression on EC 1.1.1.44 - phosphogluconate dehydrogenase (NADP+-dependent, decarboxylating)

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gene expressions is significantly repressed in the presence of nontoxic (0.87 and 3 ppm) and toxic iron concentrations (30 and 300 ppm)

Rattus norvegicus

P85968

761408

Os6PGDH1 expression is strongly induced by mechanical wounding, infestation of gravid Nilaparvata lugens females, and jasmonic acid treatment

Oryza sativa Japonica Group

Q9LI00

762190

overexpressed in number of cancer types. Upregulated expression of the enzyme (6PGD) provides metabolic as well as defensive advantage to cancer cells, thus, promoting their proliferative and metastatic potential. Enhanced 6PGD expression also performs key role in development of chemoresistance as well as radiation resistance in cancer

Homo sapiens

P52209

760658

the nontoxic (0.87 ppm) level of Fe3+ treatment leads to transcriptional activation for the enzyme

Rattus norvegicus

740634

through numerous approaches including expression vectors, hosts, cultivation conditions, inducers, and codon-optimization of the 6pgdh gene, the soluble 6PGDH expression levels are enhanced to about 250 mg per liter of culture by more than 500fold

2 entries