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2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
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-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
isocitrate + NADP+
oxalosuccinate + NADPH + H+
oxalosuccinate
2-oxoglutarate + CO2
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r
additional information
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2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
-
-
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r
2-oxoglutarate + CO2 + NADPH + H+
isocitrate + NADP+
-
-
-
r
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
enzyme is an integral part of the mitochondrial TCA cycle, and it is involved in providing NADPH for reductive reactions in the cell
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?
D-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH
-
the reaction is reversible for isozyme IDP2
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r
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
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-
-
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?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
DL-isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
ir
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
overall reaction
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
strict substrate and coenzyme specificity
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
carbon dioxide-fixing enzyme in the reductive tricarboxylic acid cycle, preference for carboxylation reaction direction
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation, involved in the tricarboxylic acid cycle
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
key enzyme of the tricarboxylic acid cycle
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
enzyme has a self-regulatory mechanism of activity mimicking the phosphorylation mechanism of bacterial enzymes
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
cytosolic enzyme is critical in fat and cholesterol biosynthesis, enzyme content correlates with adipogenesis in wild-type adipocytes and in transgenic cells
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isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
the cytosolic isozyme supplies 2-oxoglutarate for the photorespiratory ammonia fixation, pyridine nucleotide contents in mitochondria and cytosol, regulation, overview
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r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
the enzyme could have a protective antioxidant role against certain environmental stresses in plants
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isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
isocitrate dehydrogenase is an important NADPH-generating enzyme in the endoplasmic reticulum
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation, involved in the tricarboxylic acid cycle
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-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation, involved in the tricarboxylic acid cycle
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
isozymes are compartment interchangeable for glutamate synthesis, although mitochondrial localization has a positive impact on this function during fermentative growth
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?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
metabolic regulation of the isozymes
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-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + CO2 + NADPH + H+
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates
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?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
Pinus spp.
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
r
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
2-oxoglutarate + NADPH + H+ + CO2
-
-
-
-
?
isocitrate + NADP+
oxalosuccinate + NADPH + H+
-
-
-
r
isocitrate + NADP+
oxalosuccinate + NADPH + H+
-
-
-
r
additional information
?
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NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by heat shock
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?
additional information
?
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-
NADP+-dependent isocitrate dehydrogenase may play an important role in regulating the apoptosis induced by TNF-alpha and anticancer drugs
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?
additional information
?
-
the R132H mutant IDH1 directly converts 2-oxoglutarate to 2-hydroxyglutarate, that rapidly accumulates in the medium of cells expressing R132H mutant IDH1
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?
additional information
?
-
-
the R132H mutant IDH1 directly converts 2-oxoglutarate to 2-hydroxyglutarate, that rapidly accumulates in the medium of cells expressing R132H mutant IDH1
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-
?
additional information
?
-
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enzyme plays an important regulatory role in cellular defense against oxidative stress and in senescence
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?
additional information
?
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NADP+-dependent isocitrate dehydrogenase plays an important protective role in apoptosis of HL-60 cells induced by singlet oxygen
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?
additional information
?
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IDPm expression in HepG2 cells regulates ethanol-induced toxicity
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?
additional information
?
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86% of total activity in the cell, main factor for synthesis of 2-oxoglutarate. Enzyme and cytoplasmic aspartate aminotransferase are regulated oppositely and the catalytic activity of one enzyme can be stimulated concurrently with a decrease in the activity of the other
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?
additional information
?
-
suppression of enzyme activity by small interfering RNA results in impairment of glucose-stimulated insulin secretion, attenuates glucose-induced increments in pyruvate cycling activity and in NADPH levels, and causes increases in lactate production
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?
additional information
?
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during oxidative stress, enzyme activity appears to be modulated through enzymatic glutathionylation and deglutathionylation
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?