1.1.1.388: glucose-6-phosphate dehydrogenase (NAD+)
This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase (NAD+), go to the full flat file.
Reaction
Synonyms
archaeal zwischenferment, azf, Glc6PDH, HVO_0511
ECTree
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General Information
General Information on EC 1.1.1.388 - glucose-6-phosphate dehydrogenase (NAD+)
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malfunction
physiological function
compared to the wild type, the DELTAazf strain does not grow, but growth was fully recovered by in-trans complementation with azf. Growth of the deletion mutant can also be recovered by the addition of uridine to the medium, suggesting that Haloferax volcanii can circumvent the metabolic block for pentose phosphate formation via the oxidative pentose phosphate pathway by converting uridine to ribose-5-phosphate, catalyzed by uridine phosphorylase and phosphopentomutase
malfunction
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compared to the wild type, the DELTAazf strain does not grow, but growth was fully recovered by in-trans complementation with azf. Growth of the deletion mutant can also be recovered by the addition of uridine to the medium, suggesting that Haloferax volcanii can circumvent the metabolic block for pentose phosphate formation via the oxidative pentose phosphate pathway by converting uridine to ribose-5-phosphate, catalyzed by uridine phosphorylase and phosphopentomutase
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the enzyme is essential for the biosynthesis of pentose phosphates from glucose-6-phosphate during growth of Haloferax volcanii on glucose as growth substrate
physiological function
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the enzyme is essential for the biosynthesis of pentose phosphates from glucose-6-phosphate during growth of Haloferax volcanii on glucose as growth substrate
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