1.1.1.383: ketol-acid reductoisomerase [NAD(P)+]
This is an abbreviated version!
For detailed information about ketol-acid reductoisomerase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
ilvC, Shewana3_0355
ECTree
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Engineering
Engineering on EC 1.1.1.383 - ketol-acid reductoisomerase [NAD(P)+]
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A71S/R76D/S78D/Q110V
A71S/R76D/S78D/Q110V/D146G/G185R/K433E
mutant engineered for reversal in cofactor specificity for NADH over NADPH
V48L/R49P/K52E/S53D
mutant engineered for reversal in cofactor specificity for NADH over NADPH
V48L/R49P/K52L/S53D
mutant engineered for reversal in cofactor specificity for NADH over NADPH
V48L/R49P/K52L/S53D/E59K/T182S/E320K
mutant engineered for reversal in cofactor specificity for NADH over NADPH
V48L/R49P/K52E/S53D
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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V48L/R49P/K52L/S53D
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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V48L/R49P/K52L/S53D/E59K/T182S/E320K
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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A71S/R76D/S78AD/Q110V
mutant engineered for reversal in cofactor specificity for NADH over NADPH
R76D/Ser78D
mutant engineered for reversal in cofactor specificity for NADH over NADPH
A71S/R76D/S78AD/Q110V
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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R76D/Ser78D
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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S61D/S63D
mutant engineered for reversal in cofactor specificity for NADH over NADPH
S61D/S63D/I95V
mutant engineered for reversal in cofactor specificity for NADH over NADPH
S61D/S63D
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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S61D/S63D/I95V
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mutant engineered for reversal in cofactor specificity for NADH over NADPH
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additional information
recipe for altering the cofactor specificity of the ketol-acid reductoisomerases (KARIs). Combining results for an engineered NADH-dependent variant of Escherichia coli KARI with available KARI crystal structures and a comprehensive KARI-sequence alignment, key cofactor specificity determinants are identified and used to construct KARIs with reversed cofactor preference
mutant engineered for reversal in cofactor specificity for NADH over NADPH
A71S/R76D/S78D/Q110V
strain engineered to switch the cofactor specificity fromNADPH to NADH, application in an engineered Escherichia coli strain, enabling comprehensive utilization of the biomass for biofuel applications