1.1.1.378: L-rhamnose 1-dehydrogenase [NAD(P)+]
This is an abbreviated version!
For detailed information about L-rhamnose 1-dehydrogenase [NAD(P)+], go to the full flat file.
Reaction
Synonyms
AvLRA1, AvRhaDH, EAT09360, L-rhamnose 1-dehydrogenase, LRA1, NAD(P)+-dependent L-rhamnose-1-dehydrogenase, RhaDH, SpLRA1
ECTree
1.1.1.378 L-rhamnose 1-dehydrogenase [NAD(P)+]Advanced search results
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results (Substrates Products
Substrates Products on EC 1.1.1.378 - L-rhamnose 1-dehydrogenase [NAD(P)+]
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
L-fucose + NAD+
?
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-fucose + NADP+
?
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-lyxose + NAD+
?
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-mannose + NAD+
?
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-rhamnose + NAD(P)+
L-rhamno-1,4-lactone + NAD(P)H + H+
-
first enzyme of the non-phosphorylative L-rhamnose pathway in archaea, that is analogous to the Entner-Doudoroff pathway
-
-
?
L-rhamnose + NAD+
L-rhamno-1,4-lactone + NADH + H+
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-rhamnose + NADP+
L-rhamno-1,4-lactone + NADPH + H+
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
additional information
?
-
-
the C5-OH and C6-methyl groups of L-rhamnose are recognized by specific residues of RhaDH through hydrogen bonds and hydrophobic contact, respectively, which contribute to the different substrate specificities from other aldose 1-dehydrogenases in the short-chain dehydrogenase/reductase superfamily
-
-
-
L-lyxose + NADP+
?
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-lyxose + NADP+
?
-
activity is 75% compared to the activity with L-rhamnose and NADP+
-
-
?
L-lyxose + NADP+
?
-
activity is 75% compared to the activity with L-rhamnose and NADP+
-
-
?
L-mannose + NADP+
?
-
the enzyme shows significant preference for NADP+ over NAD+
-
-
?
L-mannose + NADP+
?
-
activity is 8.4% compared to the activity with L-rhamnose and NADP+
-
-
?
L-mannose + NADP+
?
-
activity is 8.4% compared to the activity with L-rhamnose and NADP+
-
-
?
L-rhamnose + NAD(P)+
L-rhamnono-1,4-lactone + NAD(P)H + H+
-
the enzyme is part of an alternative pathway of L-rhamnose metabolism by which L-rhamnose is converted into pyruvate and L-lactaldehyde, through reaction steps analogous to the Entner-Doudoroff pathway
-
-
?
L-rhamnose + NAD(P)+
L-rhamnono-1,4-lactone + NAD(P)H + H+
-
the enzyme is part of an alternative pathway of L-rhamnose metabolism by which L-rhamnose is converted into pyruvate and L-lactaldehyde, through reaction steps analogous to the Entner-Doudoroff pathway
-
-
?
L-rhamnose + NAD+
L-rhamnono-1,4-lactone + NADH + H+
-
L-rhamnose is the best substrate, preference for NADP+ over NAD+
-
-
?
L-rhamnose + NADP+
L-rhamnono-1,4-lactone + NADPH + H+
-
L-rhamnose is the best substrate, preference for NADP+ over NAD+
-
-
?
