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1.1.1.37: malate dehydrogenase

This is an abbreviated version!
For detailed information about malate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.37

Reaction

(S)-malate
+
NAD+
=
oxaloacetate
 +
NADH
 +
H+

Synonyms

(R)-2-hydroxyacid dehydrogenase, (S)-malate dehydrogenase, A8B73_11505, CaMDH, cMDH, cMDH -S, cMDH-L, cyMDH, cyMDH1, cyMDH2, cyMDH3, cytMDH, cytMDH1, cytosolic malate dehydrogenase, cytosolic malate dehydrogenase 1, cytosolic MDH, cytosolic NAD-dependent malate dehydrogenase, flo16, floury endosperm16, halophilic malate dehydrogenase, HmMalDH, L-malate dehydrogenase, L-malate dehydrogenases, L-malate-NAD oxidoreductase, L-malate-NAD-oxidoreductase, L-malate: NAD oxidoreductase, L-malate: NAD+ oxidoreductase, L-malate:NAD oxidoreductase, L-malate:NAD-oxidoreductase, L-MDH, LDH-like malate dehydrogenase, ldh0076, LEUM_0076, m-MDH, malate (NAD) dehydrogenase, malate dehydrogenase, malate dehydrogenase (NAD), malate dehydrogenase 1, malate dehydrogenase 2, malate: NAD oxidoreductase, MalDH, malic acid dehydrogenase, malic dehydrogenase, mbNAD-MDH, MDH, MDH A, MDH B1, MDH B2, Mdh1, MDH2, Mdh2a, Mdh2b, Mdh3, mitochondrial malate dehydrogenase, mitochondrial MDH, mMDH, mNAD-MDH, More, NAD+ malate dehydrogenase, NAD+-dependent malate dehydrogenase, NAD+-dependent MDH, NAD+-MDH enzymes, NAD-dependent cytosolic malate dehydrogenase, NAD-dependent malate dehydrogenase, NAD-dependent MalDH, NAD-dependent malic dehydrogenase, NAD-dependent MDH, NAD-L-malate dehydrogenase, NAD-linked malate dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, NAD-MDH, NAD-specific malate dehydrogenase, NADP+-dependent malate dehydrogenase, Pcal_1699, pdNAD-MDH, peroxisomal malate dehydrogenase, peroxisomal NAD+-malate dehydrogenase 1, peroxisomal NAD+-malate dehydrogenase 2, plastid-localized NAD-dependent MDH, plastidial NAD+-dependent malate dehydrogenase, plastidial NAD-dependent malate dehydrogenase, plastidial NAD-dependent malate dehydrogenase 1, plNAD-MDH, PMDH, PMDH1, PMDH2, regulatory subunit of nucleic acid-conducting channel, s-MDH, SrMalDH, TaMDH, VEG69, Vegetative protein 69, YlMdh2p, [LDH-like] MDH

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.37 malate dehydrogenase

Temperature Range

Temperature Range on EC 1.1.1.37 - malate dehydrogenase

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TEMPERATURE RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0 - 45
20% of maximal activity at 0°C, maximal activity at 30°C. Above the optimum temperature, the L-MDH activity tends to decrease sharply as the temperature increases, inactivation above 45°C
20 - 50
-
20°C: about 55% of maximal activity, 50°C: about 50% of maximal activity
20 - 60
-
activity range, profile overview
25 - 45
25 - 50
-
25°C: 65% of maximal activity, 50°C: about 45% of activity
30 - 58
30°C: about 50% of maximal activity, 58°C: about 55% of maximal activity
30 - 60
35 - 75
-
35°C: about 40% of maximal activity, 75°C: about 90% of maximal activity, reduction of oxaloacetate
40 - 60
profile, overview
50 - 85
between 50°C and 85°C the activity increases following the Arrhenius equation with a calculated activation energy of 61.6 kJ/mol
55 - 65
55°C: about 70% of maximal activity, 65°C: about 10% of maximal activity, wild-type enzyme
55 - 70
55°C: about 45% of maximal activity, 70°C: about 75% of maximal activity, mutant enzyme E165Q and E165K
60 - 90
-
60°C: about 45% of maximal activity, 90°C: about 60% of maximal activity
65 - 100
high activity within this range