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1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+]

This is an abbreviated version!
For detailed information about glucose-6-phosphate dehydrogenase [NAD(P)+], go to the full flat file.

Word Map on EC 1.1.1.363

Reaction

D-glucose 6-phosphate
+
NAD(P)+
=
6-phospho-D-glucono-1,5-lactone
+
NAD(P)H
+
H+

Synonyms

G6-PDH, G6PD, G6PDH, G6PDH-1, Glc6PD, Glu-6-PDH, glucose 6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, NADP+- and NAD+-dependent G6PDH, PputG6PDH-1, zwf-1

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]

General Stability

General Stability on EC 1.1.1.363 - glucose-6-phosphate dehydrogenase [NAD(P)+]

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
both after non-denaturing and after denaturing electrophoretic separation (SDS-PAGE) and blotting Leuconostoc mesenteroides G6PD retains its complete catalytic activity
-
chymotrypsin inactivates. First order rate constant for inactivation is 0.02/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+
-
eluted mutant enzyme D453C shows almost double the activity of the immobilized enzyme, which is consistent with 49% activity loss due to immobilization. Mutant enzyme D205C produces a 1.8-fold higher activity compared to its immobilized state. Eluted mutant enzyme L218C shows 9.9 times the activity of its immobilized state
-
is the result of a structural change in the enzyme caused by glucose-6-phosphate dehydrogenase. In contrast to the human enzyme, the enzyme from Pseudomonas aeruginosa is not structurally stabilized by NADP+
-
pronase inactivates. First order rate constant for inactivation is 0.012/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+
-
the substrate glucose-6-phosphate stabilizes the enzyme and protects it from heat and urea denaturation. The stabilization
-
thermolysin inactivates. First order rate constant for inactivation is 0.057/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+
-
trypsin inactivates. First order rate constant for inactivation is 0.025/min. Protection by 72 mM NAD+ or by 6.3 mM glucose 6-phosphate or 72 mM NADP+
-