1.1.1.363: glucose-6-phosphate dehydrogenase [NAD(P)+]

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For detailed information about glucose-6-phosphate dehydrogenase [NAD(P)+], go to the full flat file.

Reaction

Synonyms

G6-PDH, G6PD, G6PDH, G6PDH-1, Glc6PD, Glu-6-PDH, glucose 6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase, glucose-6-phosphate dehydrogenase Zwf, NADP+- and NAD+-dependent G6PDH, PputG6PDH-1, zwf-1

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.363 glucose-6-phosphate dehydrogenase [NAD(P)+]

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Results	in table
2	Activating Compound
56	AA Sequence
2	Application
10	Cloned(Commentary)
38	Cofactor
5	Crystallization (Commentary)
5	General Information
8	General Stability
1	IC50 Value
57	Inhibitors
102	kcat/KM [mM/s]
54	Ki Value [mM]
154	KM Value [mM]
2	Metals/Ions
6	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
3	Organic Solvent Stability
82	Organism
6	Pathway
9	pH Optimum
1	pH Range
1	pI Value
27	Protein Variants
9	Purification (Commentary)
4	Reaction
42	Reference
2	Renatured (Commentary)
10	Specific Activity [micromol/min/mg]
1	Storage Stability
75	Substrates and Products (Substrate)
5	Subunits
36	Synonyms
1	Systematic Name
11	Temperature Optimum [°C]
4	Temperature Stability [°C]
104	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.1.1.363 - glucose-6-phosphate dehydrogenase [NAD(P)+]

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

cocrystallization of and mutant enzyme Q365, mutant enzymen S215, mutant enzyme S215 with NAD+ and mutant enzyme Q365 with NADP+, hanging-drop vapour diffusion method, structures of NADP+- and NAD+-complexed enzymes are determined at 2.2 and 2.5 A resolution

Leuconostoc mesenteroides

P11411

721145

crystallized from phosphate buffer in a form suitable for X-ray crystallographic studies. The crystals diffract to better than 2.4 A. The space group is P3(1)21 (P3(2)21), a = 105.8 A, c = 225.1 A, V = 2.18 X 10(6) A(3). The asymmetric unit probably contains a single dimer

Leuconostoc mesenteroides

-

722582

hanging drop method, crystallization of six cysteine-containing mutants (Q56C, S61C, S132C, S215C, Q365C, S428C) of the enzyme and the successful preparation and crystallization of a heavy atom derivative of mutant enzyme S215C

Leuconostoc mesenteroides

P11411

723730

hanging drop vapor diffusion technique, determination of the three-dimensional structure of the D177N mutant enzyme by X-ray cryocrystallography in the presence of NAD+ and in the presence of glucose 6-phosphate plus NADPH. The structure of a glucose 6-phosphate complex of a mutant (Q365C) with normal enzyme activity is also determined and substrate binding compared

Leuconostoc mesenteroides

P11411

721583

the three-dimensional structure of the H240N glucose 6-phosphate dehydrogenase is determined at 2.5 A resolution. Crystals are grown in the presence of either glucose 6-phosphate and NAD+ or glucose 6-phosphate and NADP+, hanging drop vapor diffusion method with 2.27 M ammonium sulfate

Leuconostoc mesenteroides

-

721580