1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH)

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For detailed information about hydroxymethylglutaryl-CoA reductase (NADPH), go to the full flat file.

Reaction

Synonyms

3-hydroxy-3-methyl-glutaryl CoA reductase, 3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1, 3-hydroxy-3-methylglutaryl co-enzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase 1, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-CoA reductase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5, 3-hydroxy-3-metylglutaryl coenzyme A reductase, 3-hydroxymethylglutaryl coenzyme A reductase, acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl-Co A reductase, EuHMGR, HMG CoA reductase, HMG-CoA reductase, HMG-CoA-R, HMG-CoAR, HMG1, HMG2, HMG2.2, Hmg2p, HMG3.3, HMGCoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA), HMGCoAR, HMGCR, HMGCR1, HMGR, HMGR1, HMGR1S, HMGR2, HMGR3, HMGR5, hydroxy-3-methylglutoryl-Coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), mevalonate:NADP+ oxidoreductase (acetylating CoA), microsomal HMG-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, S-3-hydroxy-3-methylglutaryl-CoA reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)

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Results	in table
52	Activating Compound
8294	AA Sequence
12	Application
1	CAS Registry Number
36	Cloned(Commentary)
159	Cofactor
2	Crystallization (Commentary)
9030	Disease/ Diagnostics
12	Expression
148	General Information
5	General Stability
100	IC50 Value
210	Inhibitors
19	Ki Value [mM]
88	KM Value [mM]
95	Localization
50	Metals/Ions
26	Molecular Weight [Da]
196	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
566	Organism
40	Oxidation Stability
10	Pathway
108	PDB ID
76	pH Optimum
2	pH Range
10	pI Value
101	Posttranslational Modification
22	Protein Variants
37	Purification (Commentary)
5	Reaction
3	Reaction Type
174	Reference
1	Renatured (Commentary)
191	Source Tissue
26	Specific Activity [micromol/min/mg]
5	Storage Stability
277	Substrates and Products (Substrate)
70	Subunits
285	Synonyms
1	Systematic Name
61	Temperature Optimum [°C]
4	Temperature Range [°C]
4	Temperature Stability [°C]
1	Turnover Number [1/s]

Oxidation Stability

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Oxidation Stability on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)

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OXIDATION STABILITY

ORGANISM

UNIPROT

LITERATURE

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

40 entries

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Vigna radiata var. radiata

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Hordeum vulgare

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Spinacia oleracea

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Pisum sativum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Zea mays

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Solanum tuberosum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Nicotiana tabacum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Glycine max

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Lithospermum erythrorhizon

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Arabidopsis thaliana

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Picea abies

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Brassica napus

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Arachis hypogaea

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Medicago sativa

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Daucus carota

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Solanum lycopersicum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Helianthus tuberosus

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Raphanus sativus

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Gossypium hirsutum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Ochromonas malhamensis

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Hevea brasiliensis

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Persea americana

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Cucumis melo

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Cannabis sativa

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Sinapis alba

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Ipomoea batatas

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Malus domestica

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Dunaliella salina

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Euphorbia lathyris

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Nepeta cataria

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Pimpinella anisum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Parthenium argentatum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Gossypium barbadense

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Artemisia annua

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Nicotiana benthamiana

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Stevia rebaudiana

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Salvia miltiorrhiza

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Taraxacum brevicorniculatum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Solanum virginianum

-

740956

the catalytic activity of plant HMGR depends on free thiol groups and a reducing agent is used to protect their reduced state. DTT is better than 2-mercaptoethanol or glutathione for this purpose

Bixa orellana

-

740956