1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH)

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For detailed information about hydroxymethylglutaryl-CoA reductase (NADPH), go to the full flat file.

Reaction

Synonyms

3-hydroxy-3-methyl-glutaryl CoA reductase, 3-hydroxy-3-methylglutaryl Ccoenzyme A reductase 1, 3-hydroxy-3-methylglutaryl co-enzyme A reductase, 3-hydroxy-3-methylglutaryl CoA reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase, 3-hydroxy-3-methylglutaryl coenzyme A reductase 1, 3-hydroxy-3-methylglutaryl-CoA reductase, 3-hydroxy-3-methylglutaryl-CoA reductase (NADPH), 3-hydroxy-3-methylglutaryl-CoA reductase 1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase 5, 3-hydroxy-3-metylglutaryl coenzyme A reductase, 3-hydroxymethylglutaryl coenzyme A reductase, acetoacetyl-coenzyme A thiolase/3-hydroxy-3-methylglutaryl-coenzyme A reductase, beta-hydroxy-beta-methylglutaryl coenzyme A reductase, beta-hydroxy-beta-methylglutaryl-Co A reductase, EuHMGR, HMG CoA reductase, HMG-CoA reductase, HMG-CoA-R, HMG-CoAR, HMG1, HMG2, HMG2.2, Hmg2p, HMG3.3, HMGCoA reductase, HMGCoA reductase-mevalonate:NADP-oxidoreductase (acetylating CoA), HMGCoAR, HMGCR, HMGCR1, HMGR, HMGR1, HMGR1S, HMGR2, HMGR3, HMGR5, hydroxy-3-methylglutoryl-Coenzyme A reductase, hydroxymethylglutaryl CoA reductase (NADPH), hydroxymethylglutaryl-coenzyme A reductase (reduced nicotinamide adenine dinucleotide phosphate), mevalonate:NADP+ oxidoreductase (acetylating CoA), microsomal HMG-CoA reductase, NADPH-hydroxymethylglutaryl-CoA reductase, S-3-hydroxy-3-methylglutaryl-CoA reductase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.34 hydroxymethylglutaryl-CoA reductase (NADPH)

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Results	in table
52	Activating Compound
8294	AA Sequence
12	Application
1	CAS Registry Number
36	Cloned(Commentary)
159	Cofactor
2	Crystallization (Commentary)
9030	Disease/ Diagnostics
12	Expression
148	General Information
5	General Stability
100	IC50 Value
210	Inhibitors
19	Ki Value [mM]
88	KM Value [mM]
95	Localization
50	Metals/Ions
26	Molecular Weight [Da]
196	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
566	Organism
40	Oxidation Stability
10	Pathway
108	PDB ID
76	pH Optimum
2	pH Range
10	pI Value
101	Posttranslational Modification
22	Protein Variants
37	Purification (Commentary)
5	Reaction
3	Reaction Type
174	Reference
1	Renatured (Commentary)
191	Source Tissue
26	Specific Activity [micromol/min/mg]
5	Storage Stability
277	Substrates and Products (Substrate)
70	Subunits
285	Synonyms
1	Systematic Name
61	Temperature Optimum [°C]
4	Temperature Range [°C]
4	Temperature Stability [°C]
1	Turnover Number [1/s]

Crystallization

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Crystallization on EC 1.1.1.34 - hydroxymethylglutaryl-CoA reductase (NADPH)

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

analysis of the enzyme crystal structure (PDV ID 1DQA) at 2.0 A resolution

Homo sapiens

P04035

740265

enzyme in complex with inhibitor lovastatin, from 1.2 M ammonium sulfate, at 20°C, a few days, larger crystals by microseeding, complexing with the inhibitor by soaking in a KOH solution, pH 9.0, containing 2 mM lovastatin, X-ray diffraction structure determination and analysis at 2.6 A resolution

Pseudomonas mevalonii

-

656131