1.1.1.324: 8-hydroxygeraniol dehydrogenase
This is an abbreviated version!
For detailed information about 8-hydroxygeraniol dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.324
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1.1.1.324
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indole
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roseus
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10-hydroxygeraniol
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catharanthus
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iridoid
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monoterpenoids
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10-hydroxylase
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monooxygenase
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nerol
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terpenoids
- 1.1.1.324
- indole
- roseus
- 10-hydroxygeraniol
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catharanthus
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iridoid
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monoterpenoids
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10-hydroxylase
- monooxygenase
- nerol
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terpenoids
Reaction
Synonyms
10-hydroxygeraniol oxidoreductase, 8-hydroxygeraniol oxidoreductase, 8HGO, acyclic monoterpene primary alcohol:NADP+ oxidoreductase, ADH10, alcohol dehydrogenase 10, Cr10HGO, CrG10H, CYP76B10, G10H, SmG10H
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.324 - 8-hydroxygeraniol dehydrogenase
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REACTION DIAGRAM
additional information
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various branched-chain allylic primary alcohols, such as nerol, geraniol, and 8-hydroxygeraniol, are substrates, but ethanol is inert. The enzyme is also active with farnesol, 3-methyl-2-buten1-ol, citronellol, 4-isopropylbenzyl alcohol, trans-2-heptenol, and trans-2-hexenol. The enzyme exclusively transfers the pro-R hydrogen of NADPH to neral. No activity with linalool, 2,6-dimethyl-octane, iridodial, 1-octanol, 1-heptanol, 1-pentanol, 3-methyl-3-buten-1-ol, trans-crotyl alcohol, isopulegol, and menthol
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(6E)-8-oxogeranial + 2 NADPH + 2 H+
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(6E)-8-hydroxygeraniol + 2 NADP+
(6E)-8-oxogeranial + 2 NADPH + 2 H+
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oxidization at C1 and C8, depending on numbering of the molecule, GC-MS product analysis
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(6E)-8-hydroxygeraniol + 2 NADP+
(6E)-8-oxogeranial + 2 NADPH + 2 H+
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r
(6E)-8-hydroxygeraniol + 2 NADP+
(6E)-8-oxogeranial + 2 NADPH + 2 H+
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10-hydroxygeraniol undergoes a reversible dehydrogenation to produce 8-oxogeraniol or 8-hydroxygeranial, which are oxidized further to give 8-oxogeranial, the direct precursor of iridodial
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(6E)-8-hydroxynerol + 2 NADP+
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oxidization at C1 and C8, depending on numbering of the molecule, GC-MS product analysis
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