1.1.1.317: perakine reductase
This is an abbreviated version!
For detailed information about perakine reductase, go to the full flat file.
Reaction
Synonyms
AKR13D1
ECTree
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Engineering
Engineering on EC 1.1.1.317 - perakine reductase
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A213W
site-directed mutagenesis, cofactor-bound structure analysis
additional information
site-directed mutagenesis of each of the functional residues of catalytic tetrad Asp52, Tyr57, Lys84, His126 to an alanine residue results in more than 97.8% loss of enzyme activity
additional information
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site-directed mutagenesis of each of the functional residues of catalytic tetrad Asp52, Tyr57, Lys84, His126 to an alanine residue results in more than 97.8% loss of enzyme activity
additional information
methylation of wild-type and mutant enzymes for improvement of the crystallization process