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1.1.1.28: D-lactate dehydrogenase

This is an abbreviated version!
For detailed information about D-lactate dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.28

Reaction

(R)-lactate
+
NAD+
=
pyruvate
 +
NADH
 +
H+

Synonyms

D-(-)-lactate dehydrogenase, D-(-)-lactate dehydrogenase (NAD), D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding protein, D-lactate dehydrogenase, D-lactic acid dehydrogenase, D-lactic dehydrogenase, D-LDH, D-LDH-like enzyme, D-LDH0653, D-LDH1, D-LDH2, D-LDH3, D-LDH82319, D-nLDH, D-specific lactic dehydrogenase, dehydrogenase, D-lactate, DLD1, DLDH, DLDH744, ECBD_2243, ECLDH, FD35_GL001981, Fermentative lactate dehydrogenase, FN0511, FNLDH, lactic acid dehydrogenase, ldb0101, Ldb1010, LDH, LdhA, ldhd, LDHD1, LDHD2, LDHD3, LdhTi, Ljd-LDH, MGG_01202, NAD-dependent D-lactate dehydrogenase, PA0927, PALDH, Respiratory D-lactate dehydrogenase, SO_0968, tp0037, WP_013906894

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.28 D-lactate dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.28 - D-lactate dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2-oxobutyrate
-
substrate inhibition
Al3+
1 mM, 13% residual activity
Fe3+
1 mM, 73% residual activity
iodoacetamide
iodoacetate
Mg2+
1 mM, 85% residual activity
Ni2+
1 mM, 80% residual activity
oxalate
oxaloacetate
oxamate
oxygen
Ldb0101 activity is down-regulated by oxygen
p-chloromercuribenzoate
-
-
p-chloromercuriphenyl sulfonic acid
-
-
p-hydroxymercuribenzoate
phenylhydrazine
-
up to 45% inhibition
pyruvate
sodium arsenite
-
-
Triton X-100
1%, 81% residual activity
Tween 80
1%, 89% residual activity
ZnSO4
-
1 mM, 80% inhibition, EDTA restores
additional information
-