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1.1.1.272: D-2-hydroxyacid dehydrogenase (NADP+)

This is an abbreviated version!
For detailed information about D-2-hydroxyacid dehydrogenase (NADP+), go to the full flat file.

Word Map on EC 1.1.1.272

Reaction

an (R)-2-hydroxycarboxylate
+
NADP+
=
a 2-oxocarboxylate
 +
NADPH
 +
H+

Synonyms

(R)-2-hydroxyacid dehydrogenase, (R)-sulfolactate dehydrogenase, (R)-sulfolactate:NAD(P)+ oxidoreductase, 2-D-hydroxyacid dehydrogenase, 2-HDH, 2HADH, D-2-hydroxyacid dehydrogenase, D-isomer specific 2-hydroxyacid dehydrogenase, D2-HDH, DDH, DDH_HALMT, HDH, L-2-hydroxyacid dehydrogenase, L-sulfolactate dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.272 D-2-hydroxyacid dehydrogenase (NADP+)

KM Value

KM Value on EC 1.1.1.272 - D-2-hydroxyacid dehydrogenase (NADP+)

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
13.45 - 106
2-oxobutyrate
3.77 - 13.9
2-oxoisocaproate
1.31 - 11.9
2-oxoisoleucine
0.233 - 0.5
NADH
0.031 - 0.054
NADPH
21.96
pyruvate
pH 5.0, 40°C, recombinant enzyme, cofactor NADPH