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1.1.1.271: GDP-L-fucose synthase

This is an abbreviated version!
For detailed information about GDP-L-fucose synthase, go to the full flat file.

Word Map on EC 1.1.1.271

Reaction

GDP-beta-L-fucose
+
NADP+
=
GDP-4-dehydro-alpha-D-rhamnose
+
NADPH
+
H+

Synonyms

fcl, FX protein, GDP-4-keto-6-D-deoxymannose epimerase-reductase, GDP-4-keto-6-deoxy-D-mannose epimerase-reductase, GDP-4-keto-6-deoxy-D-mannose epimerase/reductase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase, GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase/reductase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, GDP-4-keto-6-deoxymannose 3, 5-epimerase 4-reductase, GDP-4-keto-6-deoxymannose 3,5-epimerase 4-reductase, GDP-4-keto-6-deoxymannose 3,5-epimerase-4-reductase, GDP-4-keto-6-deoxymannose epimerase-reductase, GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase, GDP-D-mannose-4,6-dehydratase, GDP-Fuc synthase, GDP-fucose synthase, GDP-fucose synthetase, GDP-fucose-synthesizing enzyme FX, GDP-keto-6-deoxymannose 3,5-epimerase/4-reductase, GDP-L-fucose synthetase, GDPFuc synthase, GER, GFS, GMER, guanosine diphosphofucose synthetase, P35B tumour rejection antigen, PF3D7_1014000, Red cell NADP(H)-binding protein, Transplantation antigen P35B, TSTA3, Tum-P35B antigen, wcaG

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.271 GDP-L-fucose synthase

Natural Substrates Products

Natural Substrates Products on EC 1.1.1.271 - GDP-L-fucose synthase

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NATURAL SUBSTRATE
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
GDP-4-dehydro-6-deoxy-alpha-D-mannose + NADPH + H+
GDP-beta-L-fucose + NADP+
show the reaction diagram
-
-
-
?
GDP-4-dehydro-6-deoxy-D-mannose + NADPH
GDP-L-fucose + NADP+
show the reaction diagram
GDP-4-dehydro-alpha-D-rhamnose + NADPH + H+
GDP-beta-L-fucose + NADP+
show the reaction diagram
GDP-4-keto-6-deoxy-D-mannose + NADPH
GDP-6-deoxy-L-galactose + NADP+
show the reaction diagram
-
catalyzes the last two steps in the de novo synthesis of L-fucose
-
-
?
additional information
?
-
-
fucosylation is regulated by complicated mechanisms that involve several factors: fucosyltransferases, GDP-fucose transporter, and GDP-fucose-synthetic enzymes, such as GDP-mannose 4,6-dehydratase, GDP-4-keto-6-deoxy-mannose-3,5-epimerase-4-reductase, and GDP-fucose pyrophosphorylase, fucose metabolism, overview
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?