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1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxysteroid 3-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.270

Reaction

a 3beta-hydroxysteroid
+
NADP+
=
a 3-oxosteroid
 +
NADPH
 +
H+

Synonyms

17beta-HSD7, 17beta-hydroxysteroid dehydrogenase type 7, 3-keto reducing enzyme, 3-keto reductase, 3-keto-reductase, 3-ketoreductase, 3-ketosteroid reductase, 3-KSR, 3-oxo steroid reductase, 3-oxosteroid reductase, 3beta-HSD, 3beta-HSD1, 3beta-HSD2, 3beta-HSDH, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 1, 3beta-hydroxysteroid dehydrogenase/Delta 5->4-isomerase type 2, 3beta-hydroxysteroid dehydrogenase/isomerase, AKR1C1, AKR1C2, AKR1Cs, aldo-keto reductase 1C2, CDD59473, Erg27, Erg27p, Hsd17, HSD17B7, HSD3B1, reductase, 3-oxo steroid, reductive 3beta-HSD, SDR11E1, SDR11E2, steroid-3-ketoreductase, sterol 3-ketoreductase, sterone-reducing enzyme, type 3 3alpha-hydroxysteroid dehydrogenase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.270 3beta-hydroxysteroid 3-dehydrogenase

Inhibitors

Inhibitors on EC 1.1.1.270 - 3beta-hydroxysteroid 3-dehydrogenase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(Z)-2-(4-methoxyphenylimino)-7-hydroxy-N-(pyridin-2-yl)-2H-chromene-3-carboxamide
-
noncompetitive in the reduction reaction, competitive in the oxidation reaction
16-cyano-17-keto-trilostane
selective inhibitor
-
2,16-dicyano-4,5-epoxy-androstane-3,17-dione
competitively inhibits 3beta-HSD1
-
3-(4-hydroxy-2-methoxyphenyl)acrylic acid 3-(3-hydroxyphenyl)propyl ester
-
uncompetitive in the reduction reaction, competitive in the oxidation reaction
5beta-cholanic acid-3alpha,7alpha-diol
-
-
acetonitrile
-
-
apelin
-
stimulatory effects of apelin (a regulator of ovarian physiology) on 3beta-hydroxysteroid dehydrogenase activity
-
bisdemethoxycurcumin
-
-
diethylstilbestrol
-
-
dimethyl sulfoxide
-
-
Diphenic acid
-
competitive in the oxidation reaction
epalrestat
-
-
ethanol
-
-
fenhexamid
-
Erg27 mutations causing amino acid substitutions in or near the transmembrane domain strongly decrease the affinity of fenhexamid for 3-ketoreductase. Sterol 3-ketoreductase sensitivity to fenhexamid in the various fungal strains, overview
Flufenamic acid
ionic detergents
-
inactivation by strong solutions of ionic detergents, ethylene glycol minimizes inactivation
-
itraconazole
minalrestat
-
competitive in the oxidation reaction
NADPH
oleanolic acid
-
competitive in the oxidation reaction
propan-2-ol
-
-
Tolrestat
-
competitive in the oxidation reaction
trilostane
zopolrestat
-
-
additional information
-