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1.1.1.22: UDP-glucose 6-dehydrogenase

This is an abbreviated version!
For detailed information about UDP-glucose 6-dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.22

Reaction

UDP-alpha-D-glucose
+ 2 NAD+ +
H2O
=
UDP-alpha-D-glucuronate
+ 2 NADH + 2 H+

Synonyms

ADH-like UDP-glucose dehydrogenase, AglM, BceC, Cj1441c, dehydrogenase, uridine diphosphoglucose, dual specificity UDP-glucose dehydrogenase, GbUGD, GH_D12G1806, HasB, HasB2, HVO_1531, jekyll m151, kfiD, PA2022, PA3559, PH02Gene21682, sqv-4, Sugarless protein, UDG1, UDP-alpha-D-glucose:NAD oxidoreductase, UDP-D-glucose dehydrogenase, UDP-GDH, UDP-Glc dehydrogenase, UDP-Glc DH, UDP-GlcDH, UDP-GlcDHase, UDP-glucose dehydrogenase, UDPDH, UDPG dehydrogenase, UDPG-DH, UDPG:NAD oxidoreductase, UDPGD, UDPGDH, UDPGDH-A, UDPGDH-B, UDPGlc dehydrogenase, UDPglucose dehydrogenase, UDPglucose:NAD+ oxidoreductase, Ugd, UGD1, Ugd2, UgdG, UGDH, UGDH4, uridine diphosphate D-glucose dehydrogenase, uridine diphosphate glucose dehydrogenase, uridine diphosphate glucose-6-dehydrogenase, uridine diphosphate-glucose dehydrogenase, uridine diphosphoglucose dehydrogenase, uridine-5'-diphosphoglucose dehydrogenase, uridyl phosphate dehydrogenase, VNG1048G, VNG_1048G

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.22 UDP-glucose 6-dehydrogenase

Reference

Reference on EC 1.1.1.22 - UDP-glucose 6-dehydrogenase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Jaenicke, R.; Rudolph, R.
Dissociation and in vitro reconstitution of bovine liver uridine diphosphoglucose dehydrogenase. The paired subunit nature of the enzyme
Biochemistry
25
7283-7287
1986
Bos taurus
Manually annotated by BRENDA team
Druzhinina, T.N.; Kusov, Y.Y.; Shibaev, V.N.; Kochetkov, N.K.; Biely, P.
Uridine diphosphate 2-deoxyglucose. Chemical synthesis, enzymic oxidation and epimerization
Biochim. Biophys. Acta
381
301-307
1975
Bos taurus
Manually annotated by BRENDA team
Schiller, J.G.; Lamy, F.; Frazier, R.; Feingold, D.S.
UDP-glucose dehydrogenase from Escherichia coli. Purification and subunit structure
Biochim. Biophys. Acta
453
418-425
1976
Escherichia coli
Manually annotated by BRENDA team
Schiller, J.G.; Bowser, A.M.; Feingold, D.S.
Partial purification and properties of UDPG dehydrogenase from Escherichia coli
Biochim. Biophys. Acta
293
1-10
1973
Escherichia coli
Manually annotated by BRENDA team
Davies, M.D.; Dickinson, D.B.
Properties of uridine diphosphoglucose dehydrogenase from pollen of Lilium longiflorum
Arch. Biochem. Biophys.
152
53-61
1972
Lilium longiflorum
Manually annotated by BRENDA team
Sivaswami, A.; Kelkar, S.M.; Nadkarni, G.B.
Uridine diphosphoglucose dehydrogenase from rat liver: purification and effect of pH on regulatory properties
Biochim. Biophys. Acta
276
43-52
1972
Rattus norvegicus
Manually annotated by BRENDA team
Molz, R.J.; Danishefsky, I.
Uridine diphosphate glucose dehydrogenase of rat tissue
Biochim. Biophys. Acta
250
6-13
1971
Rattus norvegicus
Manually annotated by BRENDA team
Ankel, H.; Ankel, E.; Feingold, D.S.
Biosynthesis of uridine diphosphate D-xylose. 3. Uridine diphosphate D-glucose dehydrogenase of Cryptococcus laurentii
Biochemistry
5
1864-1869
1966
Papiliotrema laurentii
Manually annotated by BRENDA team
Goldberg, N.D.; Dahl, J.L.; Parks, R.E.
pH dependence of the reactions with the 5-fluorouracil and 6-azauracil analogues of uridine diphosphate glucose
J. Biol. Chem.
238
3109-3114
1963
Bos taurus
Manually annotated by BRENDA team
Neufeld, E.F.; Hall, C.W.
Inhibition of the UDP-D-glucose dehydrogenase by UDP-D-xylose: a possible regulatory mechanism
Biochem. Biophys. Res. Commun.
19
456-461
1965
Bos taurus, Gallus gallus, Pisum sativum
Manually annotated by BRENDA team
Strominger, J.L.; Maxwell, E.S.; Axelrod, J.; Kalckar, H.M.
Enzymatic formation of uridine diphosphoglucuronic acid
J. Biol. Chem.
224
79-90
1957
Bos taurus
Manually annotated by BRENDA team
Campbell, R.E.; Sala, R.F.; van de Rijn, I.; Tanner, M.E.
Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci
J. Biol. Chem.
272
3416-3422
1997
Streptococcus pyogenes
Manually annotated by BRENDA team
Robertson, D.; Smith, C; Bolwell, G.P.
Inducible UDP-glucose dehydrogenase from french bean (Phaseolus vulgaris L.) locates to vascular tissue and has alcohol dehydrogenase activity
Biochem. J.
313
311-317
1996
Phaseolus vulgaris
Manually annotated by BRENDA team
Reen, R.K.; Jamwal, D.S.; Taneja, S.C.; Koul, J.L.; Dubey, R.K.; Wiebel, F.J.; Singh, J.
Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine
Biochem. Pharmacol.
46
229-238
1993
Cavia porcellus, Rattus norvegicus
Manually annotated by BRENDA team
Grubb, M.F.; Kasofsky, J.; Strong, J.; Anderson, L.W.; Cysyk, R.L.
Serum stimulation of UDP-glucose dehydrogenase activity in swiss 3T3 fibroblasts
Biochem. Mol. Biol. Int.
30
819-827
1993
Homo sapiens
Manually annotated by BRENDA team
Sieberth, V.; Rigg, G.P.; Roberts, I.S.; Jann, K.
Expression and characterization of UDPGlc dehydrogenase (Kfid), which is encoded in the type-specific region 2 of the Escherichia coli K5 capsule genes
J. Bacteriol.
177
4562-4565
1995
Escherichia coli
Manually annotated by BRENDA team
Hempel, J.; Perozich, J.; Romovacek, H.; Hinich, A.; Kuo, I.; Feingold, D.S.
UDP-glucose dehydrogenase from bovine liver: primary structure and relationship to other dehydrogenases
Protein Sci.
3
1074-1080
1994
Bos taurus
Manually annotated by BRENDA team
Stewart, D.C.; Copeland, L.
Kinetic properties of UDP-glucose dehydrogenase from soybean nodules
Plant Sci.
147
119-125
1999
Glycine max
-
Manually annotated by BRENDA team
Turner, W.; Botha, F.C.
Purification and kinetic properties of UDP-glucose dehydrogenase from sugarcane
Arch. Biochem. Biophys.
407
209-216
2002
Saccharum spp.
Manually annotated by BRENDA team
Roman, E.; Roberts, I.; Lidholt, K.; Kusche-Gullberg, M.
Overexpression of UDP-glucose dehydrogenase in Escherichia coli results in decreased biosynthesis of K5 polysaccharide
Biochem. J.
374
767-772
2003
Escherichia coli
Manually annotated by BRENDA team
Johansson, H.; Sterky, F.; Amini, B.; Lundeberg, J.; Kleczkowski, L.A.
Molecular cloning and characterization of a cDNA encoding poplar UDP-glucose dehydrogenase, a key gene of hemicellulose/pectin formation
Biochim. Biophys. Acta
1576
53-58
2002
Populus tremula x Populus tremuloides (Q9SQJ1)
Manually annotated by BRENDA team
Ge, X.; Penney, L.C.; van de Rijn, I.; Tanner, M.E.
Active site residues and mechanism of UDP-glucose dehydrogenase
Eur. J. Biochem.
271
14-22
2004
Streptococcus pyogenes
Manually annotated by BRENDA team
Sommer, B.J.; Barycki, J.J.; Simpson, M.A.
Characterization of human UDP-glucose dehydrogenase. CYS-276 is required for the second of two successive oxidations
J. Biol. Chem.
279
23590-23596
2004
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Huh, J.W.; Yoon, H.Y.; Lee, H.J.; Choi, W.B.; Yang, S.J.; Cho, S.W.
Importance of Gly-13 for the coenzyme binding of human UDP-glucose dehydrogenase
J. Biol. Chem.
279
37491-37498
2004
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Hinterberg, B.; Klos, C.; Tenhaken, R.
Recombinant UDP-glucose dehydrogenase from soybean
Plant Physiol. Biochem.
40
1011-1017
2002
Glycine max
-
Manually annotated by BRENDA team
Hwang, H.Y.; Horvitz, H.R.
The Caenorhabditis elegans vulval morphogenesis gene sqv-4 encodes a UDP-glucose dehydrogenase that is temporally and spatially regulated
Proc. Natl. Acad. Sci. USA
99
14224-14229
2002
Caenorhabditis elegans (Q19905), Caenorhabditis elegans
Manually annotated by BRENDA team
Bindschedler, L.V.; Wheatley, E.; Gay, E.; Cole, J.; Cottage, A.; Bolwell, G.P.
Characterisation and expression of the pathway from UDP-glucose to UDP-xylose in differentiating tobacco tissue
Plant Mol. Biol.
57
285-301
2005
Nicotiana tabacum (Q6IVK8), Nicotiana tabacum
Manually annotated by BRENDA team
Beauchef, G.; Kypriotou, M.; Chadjichristos, C.; Widom, R.L.; Poree, B.; Renard, E.; Moslemi, S.; Wegrowski, Y.; Maquart, F.X.; Pujol, J.P.; Galera, P.
c-Krox down-regulates the expression of UDP-glucose dehydrogenase in chondrocytes
Biochem. Biophys. Res. Commun.
333
1123-1131
2005
Oryctolagus cuniculus
Manually annotated by BRENDA team
Kaerkoenen, A.; Murigneux, A.; Martinant, J.P.; Pepey, E.; Tatout, C.; Dudley, B.J.; Fry, S.C.
UDP-glucose dehydrogenases of maize: a role in cell wall pentose biosynthesis
Biochem. J.
391
409-415
2005
Zea mays
Manually annotated by BRENDA team
Huh, J.W.; Lee, H.J.; Choi, M.M.; Yang, S.J.; Yoon, S.Y.; Kim, D.W.; Kim, S.Y.; Choi, S.Y.; Cho, S.W.
Identification of a UDP-glucose-binding site of human UDP-glucose dehydrogenase by photoaffinity labeling and cassette mutagenesis
Bioconjug. Chem.
16
710-716
2005
Homo sapiens
Manually annotated by BRENDA team
Huh, J.W.; Choi, M.M.; Yang, S.J.; Yoon, S.Y.; Choi, S.Y.; Cho, S.W.
Inhibition of human UDP-glucose dehydrogenase expression using siRNA expression vector in breast cancer cells
Biotechnol. Lett.
27
1229-1232
2005
Homo sapiens
Manually annotated by BRENDA team
Vigetti, D.; Ori, M.; Viola, M.; Genasetti, A.; Karousou, E.; Rizzi, M.; Pallotti, F.; Nardi, I.; Hascall, V.C.; De Luca, G.; Passi, A.
Molecular cloning and characterization of UDP-glucose dehydrogenase from the amphibian Xenopus laevis and its involvement in hyaluronan synthesis
J. Biol. Chem.
281
8254-8263
2006
Xenopus laevis (Q56R95), Xenopus laevis
Manually annotated by BRENDA team
Kaerkoenen, A.; Fry, S.C.
Novel characteristics of UDP-glucose dehydrogenase activities in maize: non-involvement of alcohol dehydrogenases in cell wall polysaccharide biosynthesis
Planta
223
858-870
2006
Zea mays
Manually annotated by BRENDA team
Huh, J.W.; Robinson, R.C.; Lee, H.S.; Lee, J.I.; Heo, Y.S.; Kim, H.T.; Lee, H.J.; Cho, S.W.; Choe, H.
Expression, purification, crystallization, and preliminary X-ray analysis of the human UDP-glucose dehydrogenase
Protein Pept. Lett.
13
859-862
2006
Homo sapiens
Manually annotated by BRENDA team
Granja, A.T.; Popescu, A.; Marques, A.R.; Sa-Correia, I.; Fialho, A.M.
Biochemical characterization and phylogenetic analysis of UDP-glucose dehydrogenase from the gellan gum producer Sphingomonas elodea ATCC 31461
Appl. Microbiol. Biotechnol.
76
1319-1327
2007
Sphingomonas elodea
Manually annotated by BRENDA team
Easley, K.E.; Sommer, B.J.; Boanca, G.; Barycki, J.J.; Simpson, M.A.
Characterization of human UDP-glucose dehydrogenase reveals critical catalytic roles for lysine 220 and aspartate 280
Biochemistry
46
369-378
2007
Homo sapiens
Manually annotated by BRENDA team
Huh, J.W.; Yang, S.J.; Hwang, E.Y.; Choi, M.M.; Lee, H.J.; Kim, E.A.; Choi, S.Y.; Choi, J.; Hong, H.N.; Cho, S.W.
Alteration of the quaternary structure of human UDP-glucose dehydrogenase by a double mutation
J. Biochem. Mol. Biol.
40
690-696
2007
Homo sapiens
Manually annotated by BRENDA team
Hung, R.J.; Chien, H.S.; Lin, R.Z.; Lin, C.T.; Vatsyayan, J.; Peng, H.L.; Chang, H.Y.
Comparative analysis of two UDP-glucose dehydrogenases in Pseudomonas aeruginosa PAO1
J. Biol. Chem.
282
17738-17748
2007
Pseudomonas aeruginosa (O86422), Pseudomonas aeruginosa (Q9HY58), Pseudomonas aeruginosa
Manually annotated by BRENDA team
Klinghammer, M.; Tenhaken, R.
Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell walls
J. Exp. Bot.
58
3609-3621
2007
Arabidopsis thaliana
Manually annotated by BRENDA team
Maneix, L.; Beauchef, G.; Servent, A.; Wegrowski, Y.; Maquart, F.X.; Boujrad, N.; Flouriot, G.; Pujol, J.P.; Boumediene, K.; Galera, P.; Moslemi, S.
17Beta-oestradiol up-regulates the expression of a functional UDP-glucose dehydrogenase in articular chondrocytes: comparison with effects of cytokines and growth factors
Rheumatology
47
281-288
2008
Oryctolagus cuniculus
Manually annotated by BRENDA team
Lee, H.S.; Son, Y.J.; Chong, S.H.; Bae, J.Y.; Leem, C.H.; Jang, Y.J.; Choe, H.
Computational analysis of the quaternary structural changes induced by point mutations in human UDP-glucose dehydrogenase
Arch. Biochem. Biophys.
486
35-43
2009
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Hwang, E.Y.; Huh, J.W.; Choi, M.M.; Choi, S.Y.; Hong, H.N.; Cho, S.W.
Inhibitory effects of gallic acid and quercetin on UDP-glucose dehydrogenase activity
FEBS Lett.
582
3793-3797
2008
Homo sapiens
Manually annotated by BRENDA team
Ariyakumar, D.S.; Nishiguchi, M.K.
Characterization of two host-specific genes, mannose-sensitive hemagglutinin (mshA) and uridyl phosphate dehydrogenase (UDPDH) that are involved in the Vibrio fischeri-Euprymna tasmanica mutualism
FEMS Microbiol. Lett.
299
65-73
2009
Aliivibrio fischeri
Manually annotated by BRENDA team
Huang, D.; Casale, G.P.; Tian, J.; Lele, S.M.; Pisarev, V.M.; Simpson, M.A.; Hemstreet, G.P.
UDP-glucose dehydrogenase as a novel field-specific candidate biomarker of prostate cancer
Int. J. Cancer
126
315-327
2009
Homo sapiens
Manually annotated by BRENDA team
Sheng, J.Z.; Ling, P.X.; Zhu, X.Q.; Guo, X.P.; Zhang, T.M.; He, Y.L.; Wang, F.S.
Use of induction promoters to regulate hyaluronan synthase and UDP-glucose-6-dehydrogenase of Streptococcus zooepidemicus expression in Lactococcus lactis: a case study of the regulation mechanism of hyaluronic acid polymer
J. Appl. Microbiol.
107
136-144
2009
Streptococcus equi subsp. zooepidemicus, Streptococcus equi subsp. zooepidemicus FHA0
Manually annotated by BRENDA team
Loutet, S.A.; Bartholdson, S.J.; Govan, J.R.; Campopiano, D.J.; Valvano, M.A.
Contributions of two UDP-glucose dehydrogenases to viability and polymyxin B resistance of Burkholderia cenocepacia
Microbiology
155
2029-2039
2009
Burkholderia cenocepacia J2315 (B4EB36), Burkholderia cenocepacia J2315 (B4EMQ8), Burkholderia cenocepacia J2315 (B4EN77)
Manually annotated by BRENDA team
Siddique, S.; Endres, S.; Atkins, J.M.; Szakasits, D.; Wieczorek, K.; Hofmann, J.; Blaukopf, C.; Urwin, P.E.; Tenhaken, R.; Grundler, F.M.; Kreil, D.P.; Bohlmann, H.
Myo-inositol oxygenase genes are involved in the development of syncytia induced by Heterodera schachtii in Arabidopsis roots
New Phytol.
184
457-472
2009
Arabidopsis thaliana (Q9FM01), Arabidopsis thaliana (Q9LF33), Arabidopsis thaliana (Q9LIA8), Arabidopsis thaliana (Q9MAB5)
Manually annotated by BRENDA team
Rocha, J.; Popescu, A.O.; Sa-Correia, I.; Fialho, A.M.; Frazao, C.
Cloning, expression, purification, crystallization and preliminary crystallographic studies of BceC, a UDP-glucose dehydrogenase from Burkholderia cepacia IST408
Acta Crystallogr. Sect. F
66
269-271
2010
Burkholderia cepacia, Burkholderia cepacia IST408
Manually annotated by BRENDA team
Rocha, J.; Granja, A.T.; Sa-Correia, I.; Fialho, A.; Frazao, C.
Cloning, expression, purification, crystallization and preliminary crystallographic studies of UgdG, an UDP-glucose dehydrogenase from Sphingomonas elodea ATCC 31461
Acta Crystallogr. Sect. F
66
69-72
2010
Sphingomonas elodea (A4UTT2), Sphingomonas elodea, Sphingomonas elodea ATCC 31461 (A4UTT2), Sphingomonas elodea ATCC 31461
Manually annotated by BRENDA team
Jiang, S.S.; Lin, T.Y.; Wang, W.B.; Liu, M.C.; Hsueh, P.R.; Liaw, S.J.
Characterization of UDP-glucose dehydrogenase and UDP-glucose pyrophosphorylase mutants of Proteus mirabilis: defectiveness in polymyxin B resistance, swarming, and virulence
Antimicrob. Agents Chemother.
54
2000-2009
2010
Proteus mirabilis (C3VI43), Proteus mirabilis
Manually annotated by BRENDA team
Wei, Q.; Galbenus, R.; Raza, A.; Cerny, R.L.; Simpson, M.A.
Androgen-stimulated UDP-glucose dehydrogenase expression limits prostate androgen availability without impacting hyaluronan levels
Cancer Res.
69
2332-2339
2009
Homo sapiens
Manually annotated by BRENDA team
Sakuraba, H.; Kawai, T.; Yoneda, K.; Ohshima, T.
Structure of a UDP-glucose dehydrogenase from the hyperthermophilic archaeon Pyrobaculum islandicum
Acta Crystallogr. Sect. F
68
1003-1007
2012
Pyrobaculum islandicum (A1RUM9), Pyrobaculum islandicum
Manually annotated by BRENDA team
Satomura, T.; Kusumi, K.; Ohshima, T.; Sakuraba, H.
Identification and characterization of UDP-glucose dehydrogenase from the hyperthermophilic archaon, Pyrobaculum islandicum
Biosci. Biotechnol. Biochem.
75
2049-2051
2011
Pyrobaculum islandicum (A1RUM9), Pyrobaculum islandicum
Manually annotated by BRENDA team
Sennett, N.C.; Kadirvelraj, R.; Wood, Z.A.
Conformational flexibility in the allosteric regulation of human UDP-alpha-D-glucose 6-dehydrogenase
Biochemistry
50
9651-9663
2011
Homo sapiens (O60701)
Manually annotated by BRENDA team
Sennett, N.C.; Kadirvelraj, R.; Wood, Z.A.
Cofactor binding triggers a molecular switch to allosterically activate human UDP-alpha-D-glucose 6-dehydrogenase
Biochemistry
51
9364-9374
2012
Homo sapiens (O60701)
Manually annotated by BRENDA team
Kadirvelraj, R.; Sennett, N.C.; Custer, G.S.; Phillips, R.S.; Wood, Z.A.
Hysteresis and negative cooperativity in human UDP-glucose dehydrogenase
Biochemistry
52
1456-1465
2013
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Rocha, J.; Popescu, A.O.; Borges, P.; Mil-Homens, D.; Moreira, L.M.; Sa-Correia, I.; Fialho, A.M.; Frazao, C.
Structure of Burkholderia cepacia UDP-glucose dehydrogenase (UGD) BceC and role of Tyr10 in final hydrolysis of UGD thioester intermediate
J. Bacteriol.
193
3978-3987
2011
Burkholderia cepacia (C9E261), Burkholderia cepacia
Manually annotated by BRENDA team
Cole, J.N.; Aziz, R.K.; Kuipers, K.; Timmer, A.M.; Nizet, V.; van Sorge, N.M.
A conserved UDP-glucose dehydrogenase encoded outside the hasABC operon contributes to capsule biogenesis in group A Streptococcus
J. Bacteriol.
194
6154-6161
2012
Streptococcus pyogenes M1 GAS (P0C0F5), Streptococcus pyogenes (Q9A0Z5), Streptococcus pyogenes 5448 (Q9A0Z5), Streptococcus pyogenes M1 GAS 5448 (P0C0F5)
Manually annotated by BRENDA team
Egger, S.; Chaikuad, A.; Klimacek, M.; Kavanagh, K.L.; Oppermann, U.; Nidetzky, B.
Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates
J. Biol. Chem.
287
2119-2129
2012
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Banerjee, N.; Bhattacharyya, D.
UDP-glucose dehydrogenase from Capra hircus liver: Purification, partial characterization and evaluation as a coupling enzyme in UDP-galactose 4-epimerase assay
J. Mol. Catal. B
68
37-43
2011
Capra hircus
-
Manually annotated by BRENDA team
Rajakannan, V.; Lee, H.S.; Chong, S.H.; Ryu, H.B.; Bae, J.Y.; Whang, E.Y.; Huh, J.W.; Cho, S.W.; Kang, L.W.; Choe, H.; Robinson, R.C.
Structural basis of cooperativity in human UDP-glucose dehydrogenase
PLoS ONE
6
e25226
2011
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Zhou, T.; Song, Y.; Feng, M.; Tan, R.
Cloning, expression and biochemical characterization of UDP-glucose 6-dehydrogenase, a key enzyme in the biosynthesis of an anti-tumor polysaccharide from the marine fungus Phoma herbarum YS4108
Process Biochem.
46
2263-2268
2011
Phoma herbarum (B5L017), Phoma herbarum YS4108 (B5L017)
-
Manually annotated by BRENDA team
Sato, K.; Hihara, E.; Yamaguchi, M.; Kanahama, K.; Kanayama, Y.
Possible role of a peach homolog of UDP-glucose dehydrogenase in fruit development
Sci. Hortic.
150
195-200
2013
Prunus persica (L0N5L6)
-
Manually annotated by BRENDA team
Yurist-Doutsch, S.; Magidovich, H.; Ventura, V.V.; Hitchen, P.G.; Dell, A.; Eichler, J.
N-glycosylation in Archaea: on the coordinated actions of Haloferax volcanii AglF and AglM
Mol. Microbiol.
75
1047-1058
2010
Haloferax volcanii (D4GYH5), Haloferax volcanii, Haloferax volcanii DSM 3757 (D4GYH5)
Manually annotated by BRENDA team
Wu, M.; Huang, H.; Li, G.; Zhou, J.; Ma, T.
Biochemical characterization and functional analysis of Udp-glucose dehydrogenase, in the synthesis of biopolymer Ss from Sphingomonas sanxanigenens NX02
Appl. Biochem. Microbiol.
51
27-33
2015
Sphingomonas sanxanigenens (W0A856), Sphingomonas sanxanigenens, Sphingomonas sanxanigenens NX02 (W0A856)
Manually annotated by BRENDA team
Wen, Y.; Li, J.; Wang, L.; Tie, K.; Magdalou, J.; Chen, L.; Wang, H.
UDP-glucose dehydrogenase modulates proteoglycan synthesis in articular chondrocytes: its possible involvement and regulation in osteoarthritis
Arthritis Res. Ther.
16
484-494
2014
Homo sapiens (O60701), Rattus norvegicus (O70199), Rattus norvegicus Wistar (O70199)
Manually annotated by BRENDA team
Barbas, A.; Popescu, A.; Frazao, C.; Arraiano, C.; Fialho, A.
Rossmann-fold motifs can confer multiple functions to metabolic enzymes: RNA binding and ribonuclease activity of a UDP-glucose dehydrogenase
Biochem. Biophys. Res. Commun.
430
218-224
2013
Sphingomonas elodea (A4UTT2), Sphingomonas elodea ATCC 31461 (A4UTT2), Sphingomonas elodea ATCC 31461
Manually annotated by BRENDA team
Li, N.; Chen, L.; Li, X.; Li, Q.; Zhang, W.; Takechi, K.; Takano, H.; Lin, X.
Overexpression of UDP-glucose dehydrogenase from Larix gmelinii enhances growth and cold tolerance in transgenic Arabidopsis thaliana
Biol. Plant.
61
95-105
2017
Larix gmelinii (A0A0E4FJQ1)
-
Manually annotated by BRENDA team
Mainprize, I.L.; Bean, J.D.; Bouwman, C.; Kimber, M.S.; Whitfield, C.
The UDP-glucose dehydrogenase of Escherichia coli K-12 displays substrate inhibition by NAD that is relieved by nucleotide triphosphates
J. Biol. Chem.
288
23064-23074
2013
Escherichia coli
Manually annotated by BRENDA team
Hyde, A.S.; Thelen, A.M.; Barycki, J.J.; Simpson, M.A.
UDP-glucose dehydrogenase activity and optimal downstream cellular function require dynamic reorganization at the dimer-dimer subunit interfaces
J. Biol. Chem.
288
35049-35057
2013
Homo sapiens (O60701)
Manually annotated by BRENDA team
Kandiba, L.; Eichler, J.
AglM and VNG1048G, two haloarchaeal UDP-glucose dehydrogenases, show different salt-related behaviors
Life
6
pii: E31
2016
Haloferax volcanii (D4GYH5), Haloferax volcanii, Halobacterium salinarum (Q9HQQ9), Halobacterium salinarum, Haloferax volcanii ATCC 29605 (D4GYH5), Halobacterium salinarum ATCC 700922 (Q9HQQ9)
Manually annotated by BRENDA team
Wei, S.; Kulinich, A.; Duan, X.C.; Liu, L.; Voglmeir, J.
Discovery and biochemical characterization of UDP-glucose dehydrogenase from Granulibacter bethesdensis
Protein Pept. Lett.
22
628-634
2015
Granulibacter bethesdensis
Manually annotated by BRENDA team
Beattie, N.R.; Keul, N.D.; Hicks Sirmans, T.N.; McDonald, W.E.; Talmadge, T.M.; Taujale, R.; Kannan, N.; Wood, Z.A.
Conservation of atypical allostery in C. elegans UDP-glucose dehydrogenase
ACS omega
4
16318-16329
2019
Caenorhabditis elegans (Q19905), Caenorhabditis elegans
Manually annotated by BRENDA team
Grady, G.; Thelen, A.; Albers, J.; Ju, T.; Guo, J.; Barycki, J.J.; Simpson, M.A.
Inhibiting hexamer disassembly of human UDP-glucose dehydrogenase by photoactivated amino acid cross-linking
Biochemistry
55
3157-3164
2016
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Beattie, N.; Keul, N.; Sidlo, A.; Wood, Z.
Allostery and hysteresis are coupled in human UDP-glucose dehydrogenase
Biochemistry
56
202-211
2017
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Beattie, N.R.; Pioso, B.J.; Sidlo, A.M.; Keul, N.D.; Wood, Z.A.
Hysteresis and allostery in human UDP-glucose dehydrogenase require a flexible protein core
Biochemistry
57
6848-6859
2018
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Riegert, A.; Raushel, F.
Functional and structural characterization of the UDP-glucose dehydrogenase involved in capsular polysaccharide biosynthesis from Campylobacter jejuni
Biochemistry
60
725-734
2021
Campylobacter jejuni subsp. jejuni (Q0P8H3), Campylobacter jejuni subsp. jejuni ATCC 700819 (Q0P8H3)
Manually annotated by BRENDA team
Vitale, D.L.; Caon, I.; Parnigoni, A.; Sevic, I.; Spinelli, F.M.; Icardi, A.; Passi, A.; Vigetti, D.; Alaniz, L.
Initial identification of UDP-glucose dehydrogenase as a prognostic marker in breast cancer patients, which facilitates epirubicin resistance and regulates hyaluronan synthesis in MDA-MB-231 cells
Biomolecules
11
246
2021
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Weyler, C.; Bureik, M.; Heinzle, E.
Selective oxidation of UDP-glucose to UDP-glucuronic acid using permeabilized Schizosaccharomyces pombe expressing human UDP-glucose 6-dehydrogenase
Biotechnol. Lett.
38
477-481
2016
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Teoh, S.T.; Ogrodzinski, M.P.; Lunt, S.Y.
UDP-glucose 6-dehydrogenase knockout impairs migration and decreases in vivo metastatic ability of breast cancer cells
Cancer Lett.
492
21-30
2020
Homo sapiens (O60701), Mus musculus (O70475), Mus musculus
Manually annotated by BRENDA team
Jia, T.; Ge, Q.; Zhang, S.; Zhang, Z.; Liu, A.; Fan, S.; Jiang, X.; Feng, Y.; Zhang, L.; Niu, D.; Huang, S.; Gong, W.; Yuan, Y.; Shang, H.
UDP-glucose dehydrogenases identification, expression, and function analyses in upland cotton (Gossypium hirsutum)
Front. Genet.
11
597890
2020
Gossypium hirsutum
Manually annotated by BRENDA team
Kasimova, A.; Kenyon, J.; Arbatsky, N.; Shashkov, A.; Popova, A.; Shneider, M.; Knirel, Y.; Hall, R.
Acinetobacter baumannii K20 and K21 capsular polysaccharide structures establish roles for UDP-glucose dehydrogenase Ugd2, pyruvyl transferase Ptr2 and two glycosyltransferases
Glycobiology
28
876-884
2018
Acinetobacter baumannii (A0A2H4ZRD7), Acinetobacter baumannii
Manually annotated by BRENDA team
Chen, J.; Yu, Y.; Gao, J.; Yang, S.
UDP-glucose dehydrogenase The first-step oxidation is an NAD+-dependent bimolecular nucleophilic substitution reaction (SN2)
Int. J. Biol. Sci.
15
341-350
2019
Streptococcus equi subsp. zooepidemicus
Manually annotated by BRENDA team
Lin, L.H.; Chou, H.C.; Chang, S.J.; Liao, E.C.; Tsai, Y.T.; Wei, Y.S.; Chen, H.Y.; Lin, M.W.; Wang, Y.S.; Chien, Y.A.; Yu, X.R.; Chan, H.L.
Targeting UDP-glucose dehydrogenase inhibits ovarian cancer growth and metastasis
J. Cell. Mol. Med.
24
11883-11902
2020
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Scoglio, S.; Lo Curcio, V.; Catalani, S.; Palma, F.; Battistelli, S.; Benedetti, S.
Inhibitory effects of Aphanizomenon flos-aquae constituents on human UDP-glucose dehydrogenase activity
J. Enzyme Inhib. Med. Chem.
31
1492-1497
2016
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Hengel, H.; Bosso-Lefevre, C.; Grady, G.; Szenker-Ravi, E.; Li, H.; Pierce, S.; Lebigot, E.; Tan, T.T.; Eio, M.Y.; Narayanan, G.; Utami, K.H.; Yau, M.; Handal, N.; Deigendesch, W.; Keimer, R.; Marzouqa, H.M.; Gunay-Aygun, M.; Muriello, M.J.; Verhelst, H.; Weckhuysen, S.; Mahida, S.; Naidu, S.; Thomas, T.G.
Loss-of-function mutations in UDP-glucose 6-dehydrogenase cause recessive developmental epileptic encephalopathy
Nat. Commun.
11
595
2020
Danio rerio (A8WGP7), Danio rerio, Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Arnold, J.M.; Gu, F.; Ambati, C.R.; Rasaily, U.; Ramirez-Pena, E.; Joseph, R.; Manikkam, M.; San Martin, R.; Charles, C.; Pan, Y.; Chatterjee, S.S.; Den Hollander, P.; Zhang, W.; Nagi, C.; Sikora, A.G.; Rowley, D.; Putluri, N.; Zhang, X.H.; Karanam, B.; Mani, S.A.; Sreekumar, A.
UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression
Oncogene
39
3089-3101
2020
Homo sapiens (O60701), Homo sapiens
Manually annotated by BRENDA team
Wei, S.; Zhang, X.Y.; Sun, Y.; Conway, L.P.; Liu, L.
Discovery and biochemical characterization of UDP-Glucose dehydrogenase from Akkermansia muciniphila
Protein Pept. Lett.
24
735-741
2017
Akkermansia muciniphila
Manually annotated by BRENDA team
Yang, Y.; Kang, L.; Wu, R.; Chen, Y.; Lu, C.
Genome-wide identification and characterization of UDP-glucose dehydrogenase family genes in moso bamboo and functional analysis of PeUGDH4 in hemicellulose synthesis
Sci. Rep.
10
10124
2020
Phyllostachys edulis
Manually annotated by BRENDA team