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1.1.1.219: dihydroflavonol 4-reductase

This is an abbreviated version!
For detailed information about dihydroflavonol 4-reductase, go to the full flat file.

Word Map on EC 1.1.1.219

Reaction

a (2R,3S,4S)-leucoanthocyanidin
+
NADP+
=
a (2R,3R)-dihydroflavonol
+
NADPH
+
H+

Synonyms

Bo9g058630, BrDFR1, BrDFR10, BrDFR11, BrDFR12, BrDFR2, BrDFR3, BrDFR4, BrDFR5, BrDFR6, BrDFR7, BrDFR8, BrDFR9, CsDFR, Cyp82C1, cytochrome P450 CYP82C1, DcDFR, DFL1, DFR, DFR1, DFR1a, DFR2, DFR3, DFR4a, DFR4b, DFR5, DgDFR, DHM reductase, DHQ reductase, dihydroflavanol 4-reductase, dihydroflavanol-4-reductase-like protein, dihydroflavonol 4-reductase, dihydroflavonol reductase, dihydroflavonol-4-reductase, dihydrokaempferol 4-reductase, dihydromyricetin reductase, dihydroquercetin reductase, DnDFR, flavan-3-ol NADPH-dihydromycertin reductase, flavonoid 3'-hydroxylase, GbDFR1, GbDFR2, GbDFR3, IbDFR, McDFR, NADPH-dihydromyricetin reductase, NtDFR1, PAS_chr3_0449, PgDFR, PhDFR, reductase, dihydromyricetin, reductase, dihydroquercetin, RrDFR1, TaDFR, TaDFR-A, TaDFR-I, TRANSPARENT TESTA 3 protein

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.219 dihydroflavonol 4-reductase

Substrates Products

Substrates Products on EC 1.1.1.219 - dihydroflavonol 4-reductase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-2,3-dihydrokaempferol + NADPH
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(+)-dihydrokaempferol + NADPH
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(+)-dihydrokaempferol + NADPH + H+
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(+)-dihydromyricetin + NADPH
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
(+)-dihydromyricetin + NADPH + H+
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
(+)-dihydroquercetin + NADPH
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
(+)-dihydroquercetin + NADPH + H+
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
(+/-)-fustin + NADPH
?
show the reaction diagram
preference for (-)-isomer
-
-
?
(+/-)-taxifolin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
?
(-)-fustin + NADPH
?
show the reaction diagram
stereospecific for (-)-isomer
-
-
?
(2E)-hex-2-enal + NADPH + H+
(2E)-hex-2-en-1-ol + NADP+
show the reaction diagram
(2R,3R)-(+)-dihydrokaempferol + NADPH
(2R,3S,4S)-cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
(2R,3R)-(+)-dihydrokaempferol + NADPH + H+
(2R,3S,4S)-cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
-
-
-
?
(2R,3R)-dihydromyricetin + NADPH
(2R,3S,4R)-3,4-leucodelphinidin + NADP+
show the reaction diagram
(2R,3R)-dihydroquercetin + NADPH
(2R,3S,4R)-leucocyanidin + NADP+
show the reaction diagram
(2S)-hexan-2-ol + NADP+
hexan-2-one + NADPH + H+
show the reaction diagram
(4S)-5,5,5-trifluoro-4-hydroxy-4-phenylpentan-2-one + NADPH + H+
(2S)-1,1,1-trifluoro-2-phenylpentane-2,4-diol + NADP+
show the reaction diagram
enzyme specifically reduces the S-enantiomer
-
-
?
2,3-dihydromyricetin + NADPH
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
low activity
-
-
?
2,3-dihydromyricetin + NADPH + H+
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
-
-
-
?
2,3-dihydroquercetin + NADPH
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
i.e. (+)-taxifolin, stereospecific for (+)-isomer
-
-
?
2,3-dihydrorobinetin + NADPH
?
show the reaction diagram
-
-
-
?
2-methylpentanal + NADPH + H+
2-methyl-pentan-1-ol + NADP+
show the reaction diagram
249% of the activity with benzaldehyde
-
-
?
7-hydroxyflavanone + NADPH + H+
2,4-cis-7-hydroxyflavan-4-ol + 2,4-trans-7-hydroxyflavan-4-ol + NADP+
show the reaction diagram
-
-
-
?
benzaldehyde + NADPH + H+
benzyl alcohol + NADP+
show the reaction diagram
butanal + NADPH + H+
butan-1-ol + NADP+
show the reaction diagram
dihydroflavonol + NADPH
flavan-3,4-diol + NADP+
show the reaction diagram
-
-
-
-
?
dihydrokaempferol + NADPH
cis-3,4-leucopelargonidin + NADP+
show the reaction diagram
-
-
-
-
r
dihydrokaempferol + NADPH + H+
leucopelargonidin + NADP+
show the reaction diagram
dihydromyricetin + NADPH
cis-3,4-leucodelphinidin + NADP+
show the reaction diagram
-
-
-
-
?
dihydromyricetin + NADPH
leucodelphinidin + NADP+
show the reaction diagram
-
-
-
-
r
dihydromyricetin + NADPH + H+
leucodelphinidin + NADP+
show the reaction diagram
dihydroquercetin + NADPH
?
show the reaction diagram
-
assay at 25°C, pH 7.5
-
-
?
dihydroquercetin + NADPH
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
dihydroquercetin + NADPH
leucocyanidin + NADP+
show the reaction diagram
-
-
-
-
r
dihydroquercetin + NADPH + H+
cis-3,4-leucocyanidin + NADP+
show the reaction diagram
dihydroquercetin + NADPH + H+
leucocyanidin + NADP+
show the reaction diagram
eriodictyol + NADPH + H+
luteoforol + NADP+
show the reaction diagram
heptan-2-one + NADPH + H+
(2S)-heptan-2-ol + NADP+
show the reaction diagram
-
99% conversion, 99% enantiomeric excess
-
r
hexan-2-one + NADPH + H+
(2S)-hexan-2-ol + NADP+
show the reaction diagram
-
99% conversion, 99% enantiomeric excess
-
r
hexanal + NADPH + H+
hexan-1-ol + NADP+
show the reaction diagram
74% of the activity with benzaldehyde
-
-
?
naringenin + NADPH + H+
apiferol + NADP+
show the reaction diagram
additional information
?
-