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1.1.1.21: aldose reductase

This is an abbreviated version!
For detailed information about aldose reductase, go to the full flat file.

Word Map on EC 1.1.1.21

Reaction

alditol
+
NAD(P)+
=
aldose
 +
NAD(P)H
 +
H+

Synonyms

17betaHSD5, 20-alpha-HSD, 20-alpha-hydroxysteroid dehydrogenase, AdhA, AKR1B, AKR1B1, AKR1B10, AKR1B13, AKR1B14, AKR1B3, AKR1C3, AKR4C7, aldehyde reductase, alditol/NADP+ oxidoreductase, alditol: NADP+ 1-oxidoreductase, alditol:NAD(P)+1oxidoreductase, alditol:NADP 1-oxidoreductase, alditol:NADP oxidoreductase, aldo-keto reductase, aldo-keto reductase family 1 member B1, aldo-keto reductase family 1 member B7, aldoketo reductase 1C3, aldose reductase, aldose reductase 2, aldose reductase-like, aldose reductase-like protein, aldose xylose reductase, ALDRXV4, ALR, ALR1, ALR2, AR, ARI, BAR, EC 1.1.1.139, Fibroblast growth factor regulated protein, FR-1 protein, GRE3, HAR, HRAR, isobutyraldehyde reductase, More, MVDP, NADPH dependent xylose reductase, NADPH-aldopentose reductase, NADPH-aldose reductase, polyol dehydrogenase (NADP2), RLAR, small intestine reductase, TPN-polyol dehydrogenase, VAS deferens androgen-dependent protein, YqhD

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.21 aldose reductase

KI Value

KI Value on EC 1.1.1.21 - aldose reductase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0182 - 3.081
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid
0.0167 - 0.328
(2-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid
0.00044
(3-methyl-1-oxo-5-phenylpyrimido[4,5-c]quinolin-2(1H)-yl)acetic acid
pH 7.5, 25°C
0.00004 - 0.0078
(5-chloro-2-[(4-cyanobenzyl)carbamoyl]phenoxy)acetic acid
0.0088
1,2,7-trihydroxy-3,8-dimethoxy-6-methylanthracene-9,10-dione 2-O-beta-D-glucoside
-
pH 7.0, 37°C
0.0136
1,3,7-trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione
-
pH 7.0, 37°C
0.0159
1,3,8-trihydroxy-6-methylanthracene-9,10-dione
-
pH 7.0, 37°C
0.0241
3,3-Tetramethyleneglutaric acid
-
pH 7.0, 37°C
0.0141
4-amino-N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
-
0.00297
6-[[(di(2,4-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37°C
0.00299
6-[[(di(3,5-dimethoxyphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37°C
0.00292
6-[[(di(4-methoxy-3-methylphenyl)methylidene)amino]oxy]hexanoic acid
-
pH 6.8, 37°C
0.0011 - 0.0026
bezafibrate
-
pH 6.2, 25°C, recombinant enzyme
0.0089 - 0.597
capsaicin
0.00088
ciprofibrate
-
pH 6.2, 25°C, recombinant enzyme
0.00124
Clofibric acid
-
pH 6.2, 25°C, recombinant enzyme
0.00033 - 0.00056
davallialactone
0.00063 - 0.00137
ellagic acid
0.00056
fenofibrat
-
pH 6.2, 25°C, recombinant enzyme
0.0012 - 0.0037
gemfibrozil
-
pH 6.2, 25°C, recombinant enzyme
0.00082 - 0.00128
hypholomine B
0.0155
N-(3,5-difluoro-4-hydroxyphenyl)-4-methoxybenzenesulfonamide
-
-
0.0444
N-(3,5-difluoro-4-hydroxyphenyl)-4-nitrobenzenesulfonamide
-
-
0.0329
N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
-
0.01355
nitazoxanide
-
pH and temperature not specified in the publication
0.00045
sorbinil
-
pH 6.2, 25°C, recombinant enzyme
0.000458
sulindac
pH 6.2, temperature not specified in the publication, ALR2
0.0003
sulindac sulfide
pH 6.2, temperature not specified in the publication, ALR2
0.000434
sulindac sulfone
pH 6.2, temperature not specified in the publication, ALR2
0.00935
tizoxanide
-
pH and temperature not specified in the publication
0.000005 - 0.000043
zopolrestat
0.00015
[5-(4-bromophenyl)-3-methyl-1-oxopyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
0.00013
[5-(4-chlorophenyl)-1-oxo-3-propylpyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
0.000073
[5-(4-chlorophenyl)-3-ethyl-1-oxopyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
0.0005
[5-(4-chlorophenyl)-3-ethyl-9-fluoro-1-oxopyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
0.00013
[5-(4-chlorophenyl)-3-methyl-1-oxopyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
0.00024
[5-(4-chlorophenyl)-9-fluoro-3-methyl-1-oxopyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
0.00024
[9-fluoro-5-(4-methoxyphenyl)-3-methyl-1-oxopyrimido[4,5-c]quinolin-2(1H)-yl]acetic acid
pH 7.5, 25°C
additional information
additional information
-