1.1.1.205: IMP dehydrogenase

This is an abbreviated version!
For detailed information about IMP dehydrogenase, go to the full flat file.

Reaction

Synonyms

A1S_3321, BTH_I2056, class I IMPDH, class II IMPDH, dehydrogenase, inosinate, DR63_268, EC 1.2.1.14, GBAA_0008, guaB, guaB2, IMD2, IMD3, IMD4, IMP dehydrogenase, IMP DH, IMP oxidoreductase, IMP-DH, IMP:NAD oxidoreductase, IMP:NAD+ oxidoreductase, IMPD, IMPDH, IMPDH II, IMPDH-1, IMPDH-B, IMPDH-S, IMPDH1, IMPDH2, IMPDHA, IMPDHab, IMPDHba, IMPDHbt, IMPDHI, IMPDHII, IMPDHkp, IMPDHlpp, IMPDHnm, IMPDHpa, inosinate dehydrogenase, inosine 5' monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase, inosine 5'-monophosphate dehydrogenase 2, inosine 5'-phosphate dehydrogenase, inosine 5-monophosphate dehydrogenase, inosine 5-monophosphate dehydrogenase 2, inosine 5-monophosphate dehydrogenase type I, inosine 5� -monophosphate dehydrogenase, inosine 5�-monophosphate dehydrogenase 2, inosine monophosphate dehydrogenase, inosine monophosphate dehydrogenase-1, inosine monophosphate dehydrogenase-2, inosine monophosphate oxidoreductase, inosine-5'-monophosphate dehydrogenase, inosine-5'-phosphate dehydrogenase, inosine-5-monophosphate dehydrogenase, inosinic acid 5�-monophosphate dehydrogenase, inosinic acid dehydrogenase, lpg1723, mpaF, NMC1103, Raspberry protein, Rv3411c, SOI12, Superoxide-inducible protein 12, type 1 inosine monophosphate, type 2 inosine monophosphate dehydrogenase

ECTree

     1 Oxidoreductases

         1.1 Acting on the CH-OH group of donors

             1.1.1 With NAD⁺ or NADP⁺ as acceptor

                1.1.1.205 IMP dehydrogenase

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Results	in table
37	Activating Compound
43951	AA Sequence
38	Application
1	CAS Registry Number
83	Cloned(Commentary)
197	Cofactor
44	Crystallization (Commentary)
1367	Disease/ Diagnostics
5	Expression
126	General Information
8	General Stability
294	IC50 Value
1189	Inhibitors
5	kcat/KM [mM/s]
366	Ki Value [mM]
230	KM Value [mM]
13	Localization
72	Metals/Ions
75	Molecular Weight [Da]
133	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
726	Organism
9	Pathway
561	PDB ID
57	pH Optimum
11	pH Range
105	Protein Variants
87	Purification (Commentary)
29	Reaction
3	Reaction Type
312	Reference
2	Renatured (Commentary)
132	Source Tissue
39	Specific Activity [micromol/min/mg]
18	Storage Stability
292	Substrates and Products (Substrate)
80	Subunits
431	Synonyms
1	Systematic Name
41	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
93	Turnover Number [1/s]

Expression

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Expression on EC 1.1.1.205 - IMP dehydrogenase

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

downregulation of impdh expression under heat shock treatment

Leishmania amazonensis

Q2TUW2

740417

enhanced expression of the type 2 isozyme in leukemias and other proliferating human cells

Homo sapiens

-

701583

IMPDH protein expression is transiently increased during differentiation of 3T3-L1 preadipocytes. Total IMPDH protein levels and activity are highest around day 3

Mus musculus

-

702061

increase in IMPDH activity in erythrocytes after kidney transplantation

Homo sapiens

-

703272

isoform IMPDH2 expression is increased in glioblastoma

Homo sapiens

P12268

761406