1.1.1.18: inositol 2-dehydrogenase
This is an abbreviated version!
For detailed information about inositol 2-dehydrogenase, go to the full flat file.
Reaction
Synonyms
BsIDH, cg0204, GK1898, IDH, inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase, inositol dehydrogenase, iolG, iolG1, iolG2, LcIDH1, LcIDH2, MI dehydrogenase, More, myo-inositol 2-dehydrogenase, myo-inositol dehydrogenase, myo-inositol:NAD2 oxidoreductase
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Natural Substrates Products
Natural Substrates Products on EC 1.1.1.18 - inositol 2-dehydrogenase
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REACTION DIAGRAM
D-2,3-diketo-4-deoxy-epi-inositol + NADH
ketodeoxyinositol + NAD+
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additional information
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the enzyme shows a broad substrate spectrum while remaining highly stereoselective. BsIDH is able to oxidize the mono-saccharides alpha-D-glucose and alpha-D-xylose but not beta-D-glucose, D-mannose and D-galactose
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2,3,4,5,6-pentahydroxycyclohexanone + NADH + H+
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myo-inositol + NAD+
2,3,4,5,6-pentahydroxycyclohexanone + NADH + H+
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2,4,6/3,5-pentahydroxycyclohexanone + NADH
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
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should be classified as A-type enzyme
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
involved in nitrogen fixation and nodulation of soybean
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
involved in nitrogen fixation and nodulation of soybean
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
involved in rhizopine utilization
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH
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2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
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i.e. scyllo-inosose
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
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myo-inositol + NAD+
2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+
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i.e. scyllo-inosose
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myo-inositol + NAD+
scyllo-inosose + NADH
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first enzyme in the catabolic pathway of myo-inositol
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r
myo-inositol + NAD+
scyllo-inosose + NADH
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75 times lower activity compared to the reverse reaction
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r
myo-inositol + NAD+
scyllo-inosose + NADH + H+
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the NAD+-dependent enzyme catalyses the oxidation of the axial hydroxyl group of myo-inositol to form scyllo-inosose
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i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway
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pinitol + NADH + H+
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i.e. 3-O-methyl-D-chiro-inositol. Bacillus subtilis can utilize pinitol as the sole carbon source via the same myo-inositol catabolic pathway
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