1.1.1.162: erythrulose reductase
This is an abbreviated version!
For detailed information about erythrulose reductase, go to the full flat file.
Reaction
Synonyms
D-erythrulose reductase, D-threitol:NADP+ oxidoreductase, reductase, D-erythrulose
ECTree
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Substrates Products
Substrates Products on EC 1.1.1.162 - erythrulose reductase
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REACTION DIAGRAM
acetoin + NADPH + H+
2,3-butanediol + NADP+
-
only slight reversibility, low activity
-
r
D-erythrulose + NAD(P)+
?
-
one route of formation of tetritols in mammalia
-
-
r
isatin + NADPH
?
-
s-cis configuration of the neighbouring carbonyls is important for activity
-
-
?
Phenanthrenequinone + NADPH
?
-
s-cis configuration of the neighbouring carbonyls is important for activity
-
-
?
D-threitol + NAD(P)+
-
several substrates listed that do not serve as substrates
-
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
highly specific for D-erythrulose
-
ir
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
highly specific for D-erythrulose
-
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
highly specific for D-erythrulose
in reference 2 the enzymatic reaction product of D-erythrulose is incorrectly identified as erythritol, gas-liquid and thin-layer chromatographic data have confirmed the product to be D-threitol, not erythritol, for this reason the systematic name D-threitol:NADP+ oxidoreductase should be used instead of erythritol:NADP+ oxidoreductase which has been designated by the IUB Enzyme commission
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
reversibility could not be demonstrated
-
ir
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
the equilibrium of the reaction strongly favors the reduction of D-erythrulose, the reverse reaction is slightly detectable when carried out at pH 7.5-9.0 using NADP+, erythritol does not serve as substrate
in reference 2 the enzymatic reaction product of D-erythrulose is incorrectly identified as erythritol, gas-liquid and thin-layer chromatographic data have confirmed the product to be D-threitol, not erythritol, for this reason the systematic name D-threitol:NADP+ oxidoreductase should be used instead of erythritol:NADP+ oxidoreductase which has been designated by the IUB Enzyme commission
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
several substrates listed that do not serve as substrates
-
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
highly specific for D-erythrulose
-
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
highly specific for D-erythrulose
reverse reaction rate is very low
r
D-erythrulose + NAD(P)H
D-threitol + NAD(P)+
-
the equilibrium of the reaction strongly favors the reduction of D-erythrulose, the reverse reaction is slightly detectable when carried out at pH 7.5-9.0 using NADP+, erythritol does not serve as substrate
reverse reaction rate is very low
r
acetoin + NADP+
-
utilizes mainly vicinal alpha-dicarbonyls
-
?, ir
diacetyl + NAD(P)H
acetoin + NADP+
-
reaction is also performed by acetoin:NAD+ oxidoreductase, EC 1.1.1.5
-
?, ir
diacetyl + NAD(P)H
acetoin + NADP+
-
specific for alpha-dicarbonyls
-
?, ir
diacetyl + NAD(P)H
acetoin + NADP+
-
detoxification of food derived dicarbonyls
-
ir