1.1.1.16: galactitol 2-dehydrogenase
This is an abbreviated version!
For detailed information about galactitol 2-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.16
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1.1.1.16
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dehydrogenases
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polyols
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rhodobacter
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sphaeroides
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xylitol
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l-tagatose
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d-galactose
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diol
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1,2-hexanediol
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ribitol
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nad+-dependent
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s-1,2-propanediol
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his6-tagged
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leloir
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4-dehydrogenase
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synthesis
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l-arabitol
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nidulans
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regioselective
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l-xylulose
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rhizobium
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bioconversion
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hydroxyacetone
- 1.1.1.16
- dehydrogenases
- polyols
-
rhodobacter
- sphaeroides
- xylitol
- l-tagatose
- d-galactose
- diol
- 1,2-hexanediol
- ribitol
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nad+-dependent
- s-1,2-propanediol
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his6-tagged
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leloir
-
4-dehydrogenase
- synthesis
- l-arabitol
- nidulans
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regioselective
- l-xylulose
- rhizobium
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bioconversion
- hydroxyacetone
Reaction
Synonyms
dulcitol dehydrogenase, galactitol dehydrogenase, GDH, Lad1, LadB
ECTree
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General Information
General Information on EC 1.1.1.16 - galactitol 2-dehydrogenase
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evolution
malfunction
metabolism
additional information
evolution
galactitol 2-dehydrogenase belongs to the protein subfamily of short-chain dehydrogenases/reductases
evolution
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galactitol 2-dehydrogenase belongs to the protein subfamily of short-chain dehydrogenases/reductases
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evolution
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LadB belongs to the medium-chain dehydrogenases
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deletion of ladB in Aspergillus niger results in growth arrest on galactitol and significantly slower growth on D-galactose supplemented with a small amount of D-xylose. D-Galactose alone cannot be utilised by Aspergillus niger and the addition of D-xylose stimulates growth on D-galactose via transcriptional activation of the D-xylose-inducible reductase gene, xyrA
malfunction
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deletion of ladB in Aspergillus niger results in growth arrest on galactitol and significantly slower growth on D-galactose supplemented with a small amount of D-xylose. D-Galactose alone cannot be utilised by Aspergillus niger and the addition of D-xylose stimulates growth on D-galactose via transcriptional activation of the D-xylose-inducible reductase gene, xyrA
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LadB catalyzes a step in the oxido-reductive pathway for D-galactose catabolism in filamentous fungi, overview
metabolism
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LadB catalyzes a step in the oxido-reductive pathway for D-galactose catabolism in filamentous fungi, overview
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homology modeling and sequence analysisA , overview. The active site contains residues Asn119,Ser147, Tyr162, and Lys166 which are conserved in short-chain dehydrogenases/reductases
additional information
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homology modeling and sequence analysisA , overview. The active site contains residues Asn119,Ser147, Tyr162, and Lys166 which are conserved in short-chain dehydrogenases/reductases
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