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1.1.1.145: 3beta-hydroxy-DELTA5-steroid dehydrogenase

This is an abbreviated version!
For detailed information about 3beta-hydroxy-DELTA5-steroid dehydrogenase, go to the full flat file.

Word Map on EC 1.1.1.145

Reaction

a 3beta-hydroxy-DELTA5-steroid
+
NAD+
=
a 3-oxo-DELTA5-steroid
+
NADH
+
H+

Synonyms

3 beta- and steroid deltaisomerase 1, 3-beta-hydroxy-5-ene steroid dehydrogenase, 3-beta-hydroxy-delta(5)-steroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase, 3-beta-hydroxysteroid dehydrogenase type-2, 3beta hydroxysteroid dehydrogenase, 3beta-HSD, 3beta-HSD type II, 3beta-HSD1, 3beta-HSD2, 3beta-HSD22, 3beta-HSDH, 3beta-HSD_1, 3beta-hydroxy steroid dehydrogenase/5-ene-4-ene isomerase, 3beta-hydroxy steroid dehydrogenase/isomerase, 3beta-hydroxy-5-ene steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid dehydrogenase, 3beta-hydroxy-5-ene-steroid oxidoreductase, 3beta-hydroxy-DELTA5-C27-steroid dehydrogenase/isomerase, 3beta-hydroxy-DELTA5-C27-steroid oxidoreductase, 3beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase 1, 3beta-hydroxysteroid dehydrogenase 2, 3beta-hydroxysteroid dehydrogenase type 1, 3beta-hydroxysteroid dehydrogenase type 2, 3beta-hydroxysteroid dehydrogenase type 2 and, 3beta-hydroxysteroid dehydrogenase type II, 3beta-hydroxysteroid dehydrogenase type1, 3beta-hydroxysteroid dehydrogenase/3-ketosteroid reductase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELAT4 isomerase type 2, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4 isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase, 3beta-hydroxysteroid dehydrogenase/DELTA5-DELTA4-isomerase type II, 3beta-hydroxysteroid dehydrogenase/isomerase, 3beta-hydroxysteroid dehydrogenase/isomerase type 1, 3beta-hydroxysteroid dehydrogenase/steroid DELTA5,4-isomerase, 3betaHSD, 3betaHSD1, 3betaHSD2, 5-ene-3-beta-hydroxysteroid dehydrogenase, 5alpha-dihydrotestosterone 3beta-hydroxysteroid dehydrogenase, dehydrogenase, 3beta-hydroxy-DELTA5-steroid, DELTA5-3beta-hydroxysteroid dehydrogenase, DHRS4, HSD2, HSD3B, HSD3B1, HSD3B2, Hsd3b6, HSDB1, HSDH, More, progesterone reductase, Sl3betaHSD1, Solyc01g73640, steroid-DELTA5-3beta-ol dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase, type 1 3beta-hydroxysteroid dehydrogenase/isomerase, type 2 3beta-hydroxysteroid dehydrogenase, type 2 3beta-hydroxysteroid dehydrogenase/isomerase

ECTree

     1 Oxidoreductases
         1.1 Acting on the CH-OH group of donors
             1.1.1 With NAD+ or NADP+ as acceptor
                1.1.1.145 3beta-hydroxy-DELTA5-steroid dehydrogenase

Substrates Products

Substrates Products on EC 1.1.1.145 - 3beta-hydroxy-DELTA5-steroid dehydrogenase

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(S)-1-indanol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
(S)-1-tetralol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
(S)-phenyl-1-butanol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
1,4-naphthoquinone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
r
1-phenylisatin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
11beta,17alpha,21-trihydroxy-4-pregnen-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
11beta,17alpha,21-trihydroxy-5alpha-pregnane-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-5alpha-pregnan-20-one + NADP+
show the reaction diagram
-
-
-
-
?
11beta,17alpha,21-trihydroxy-5beta-pregnane-3,20-dione + NADPH
3beta,11beta,17alpha,21-tetrahydroxy-5beta-pregnan-20-one + NADP+
show the reaction diagram
-
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2 + NADPH
?
show the reaction diagram
-
-
-
-
?
13,14-dihydro-15-keto-prostaglandin F2alpha + NADPH
?
show the reaction diagram
-
-
-
-
?
16alpha-hydroxy-dehydroepiandrosterone + NAD+
?
show the reaction diagram
-
-
-
?
16alpha-hydroxy-dehydroepiandrosterone + NAD+
? + NADH
show the reaction diagram
-
-
-
?
16beta-hydroxy-dehydroepiandrosterone + NAD+
?
show the reaction diagram
-
-
-
?
16beta-hydroxy-dehydroepiandrosterone + NAD+
? + NADH
show the reaction diagram
-
-
-
?
17-hydroxyprogesterone + NADPH
3beta,17-dihydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
17alpha-hydroxypregnenolone + NAD+
17alpha-hydroxy-pregn-5-en-3,20-dione + NADH
show the reaction diagram
17beta-hydroxy-5alpha-androstane-3-one + NADPH
3beta,17beta-dihydroxy-5alpha-androstane + NADP+
show the reaction diagram
-
-
-
-
?
17beta-hydroxy-5beta-androstane-3-one + NADPH
3beta,17beta-dihydroxy-5beta-androstane + NADP+
show the reaction diagram
-
-
-
-
?
2,3-heptanedione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
2,3-hexanedione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
2,3-pentanedione + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
r
3beta,17alpha-dihydroxy-5-pregnen-20-one + NAD(P)+
17alpha-hydroxypregn-5-ene-3,20-dione + NAD(P)H
show the reaction diagram
3beta,7alpha-dihydroxy-5-cholestenoic acid + NAD+
7alpha-hydroxy-3-oxo-5-cholestenoic acid + NADH
show the reaction diagram
-
-
-
-
?
3beta-hydroxy-5-androsten-17-one + NAD+
androstendione + NADH + H+
show the reaction diagram
3beta-hydroxyandrostan-17-one + NAD+
androstan-3,17-dione + NADH
show the reaction diagram
-
-
-
-
?
4,4'-dimethylbenzil + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-androsten-17beta-ol-3-one + NADH + H+
4-androsten-3beta,17beta-diol + NAD+
show the reaction diagram
-
-
-
r
4-androsten-3beta,17beta-diol + NAD+
4-androsten-17beta-ol-3-one + NADH
show the reaction diagram
-
-
-
-
?
4-benzoylpyridine + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-benzylpyridine + NADPH
?
show the reaction diagram
-
-
-
-
?
4-carboxybenzaldehyde + NADP+ + H2O
4-carboxybenzoic acid + NADPH + H+
show the reaction diagram
-
-
-
-
?
4-hexanoylpyridine + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
4-nitroacetophenone + NADPH
1-(4-nitrophenyl)ethanol + NADP+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
4-nitrobenzyl alcohol + NADP+
show the reaction diagram
-
-
-
-
?
4-nitrobenzaldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
5,16-androstadien-3beta-ol + NAD+
5,16-androstadien-3-one + NADH
show the reaction diagram
-
-
-
-
?
5-androsten-3beta-ol-17-one + NAD+
5-androsten-3,17-dione + NADH
show the reaction diagram
-
-
-
r
5-pregnen-3beta-ol-2-one + NAD+
progesterone + NADH
show the reaction diagram
5alpha-androstan-3beta-ol-17-one + NADP+
5alpha-androstan-3,17-dione + NADPH
show the reaction diagram
5alpha-androstane-3,17-dione + NADPH
3beta-hydroxy-5alpha-androstane-17-one + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-androstane-3,17-dione + NADPH
5alpha-androstane-3beta-ol-17-one + NADP+
show the reaction diagram
-
-
-
-
r
5alpha-androstane-3beta,17beta-diol + NADP+
5alpha-androstane-17beta-ol-3-one + NADPH
show the reaction diagram
-
-
-
-
r
5alpha-androstanediol + NAD+
5alpha-dihydrotestosterone + NADH
show the reaction diagram
-
-
-
-
r
5alpha-dihydrotestosterone + NADPH
5alpha-androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
?
5alpha-dihydrotestosterone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
5alpha-pregnan-3beta-ol-20-one + NAD+
5alpha-pregnan-3,20-dione + NADH
show the reaction diagram
-
-
-
-
?
5alpha-pregnane-3,20-dione + NAD(P)H
5alpha-pregnane-3beta-ol-20-one + NAD(P)+
show the reaction diagram
5alpha-pregnane-3,20-dione + NADH
5alpha-pregnane-3beta-ol-20-one + NAD+
show the reaction diagram
-
-
-
r
5alpha-pregnane-3beta-ol-20-one + NAD+
5alpha-pregnane-3,20-dione + NADH
show the reaction diagram
-
-
-
r
5alpha-pregnane-3beta-ol-20-one + NADP+
5alpha-pregnane-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
r
5beta-androstan-17beta-ol-3-one + NADPH
5beta-androstane-3beta,17beta-diol + NADP+
show the reaction diagram
-
-
-
-
r
5beta-androstan-3beta-ol-17-one + NADP+
5beta-androstane-3,17-dione + NADPH
show the reaction diagram
-
-
-
-
r
5beta-androstane-3,17-dione + NADPH
3beta-hydroxy-5beta-androstane-17-one + NADP+
show the reaction diagram
-
-
-
-
?
5beta-androstane-3,17-dione + NADPH
5beta-androstan-3beta-ol-17-one + NADP+
show the reaction diagram
-
-
-
-
r
5beta-androstane-3beta,17beta-diol + NADP+
5beta-androstan-17beta-ol-3-one + NADPH
show the reaction diagram
-
-
-
-
r
5beta-pregnan-20alpha-ol-3-one + NADPH + H+
5beta-pregnan-3beta,20alpha-diol + NADP+
show the reaction diagram
-
-
-
-
r
5beta-pregnan-3beta-ol-20-one + NADP+
5beta-pregnan-3,20-dione + NADPH
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3,20-dione + NAD(P)H + H+
5beta-pregnane-3beta-ol-20-one + NAD(P)+
show the reaction diagram
5beta-pregnane-3,20-dione + NADH + H+
5beta-pregnane-3beta-ol-20-one + 5beta-pregnane-3alpha-ol-20-one + NAD+
show the reaction diagram
-
-
-
r
5beta-pregnane-3,20-dione + NADPH + H+
5beta-pregnan-3beta-ol-20-one + NADP+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3beta,20alpha-diol + NADP+
5beta-pregnane-20alpha-ol-3-one + NADPH + H+
show the reaction diagram
-
-
-
-
r
5beta-pregnane-3beta-ol-20-one + NAD+
5beta-pregnane-3,20-dione + NADH + H+
show the reaction diagram
-
-
-
r
6-tert-butyl-2,3-epoxy-5-cyclohexene-1,4-dione + NADPH
? + NADP+
show the reaction diagram
-
major product has S-configuration
-
-
r
7alpha,25-dihydroxycholesterol + NAD+
7alpha,25-dihydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
7alpha,27-dihydroxycholesterol + NAD+
7alpha,27-dihydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
7alpha-hydroxycholesterol + NAD+
7alpha-hydroxy-4-cholesten-3-one + NADH
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
?
show the reaction diagram
-
-
-
-
?
9,10-phenanthrenequinone + NADPH
? + NADP+
show the reaction diagram
all-trans-retinal + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
all-trans-retinol + NADP+
? + NADPH
show the reaction diagram
-
-
-
-
r
allopregnanolone + NAD+
?
show the reaction diagram
-
-
-
-
r
androst-5-en-3,17-dione + NADH
dehydroepiandrosterone + NAD+
show the reaction diagram
-
-
-
r
androst-5-ene-3beta-ol-17-one + NAD+
androst-5-ene-3,17-dione + NADH
show the reaction diagram
androstanediol + NAD+
dihydrotestosterone + NADH + H+
show the reaction diagram
-
-
-
-
r
androstendiol + NAD+
testosterone + NADH + H+
show the reaction diagram
androstenediol + NAD+
testosterone + NADH + H+
show the reaction diagram
-
-
-
-
r
androstenedione + NADPH + H+
3beta-hydroxy-5-androsten-17-one + NADP+
show the reaction diagram
-
-
-
-
?
androstenone + NAD+
5alpha-androst-16-en-3beta-ol + NADH + H+
show the reaction diagram
-
-
-
-
?
androstenone + NADH
beta-androstenol + NAD+
show the reaction diagram
-
-
-
?
benzil + NADPH
(R)-benzoin + NADP+
show the reaction diagram
-
enantiomeric purity of 97% enantiomeric excess
-
-
r
camphorquinone + NADPH + H+
camphorquinol + NADP+
show the reaction diagram
-
-
-
-
?
caprinaldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
cholesterol + NAD+
cholest-5-en-3-one + NADH
show the reaction diagram
-
-
-
-
?
cyclohexanone + NADPH
cyclohexanol + NADP+
show the reaction diagram
-
-
-
-
?
D-galactose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucose + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glucuronic acid + NADPH
?
show the reaction diagram
-
-
-
-
?
D-glyceraldehyde + NADPH
?
show the reaction diagram
-
-
-
-
?
D-xylose + NADPH
?
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NAD+
5-androstene-3,17-dione + NADH + H+
show the reaction diagram
-
-
-
?
dehydroepiandrosterone + NAD+
?
show the reaction diagram
dehydroepiandrosterone + NAD+
androst-5-en-3,17-dione + NADH + H+
show the reaction diagram
dehydroepiandrosterone + NAD+
androstenedione + NADH + H+
show the reaction diagram
dehydroepiandrosterone + NADH + H+
androsterone + NAD+
show the reaction diagram
-
-
-
-
?
dehydroepiandrosterone + NADPH
3beta-hydroxy-5-androsten-17-one + NADP+
show the reaction diagram
-
-
-
-
?
dehydrolithocholic acid + NADPH
isolithocholic acid + NADP+
show the reaction diagram
-
-
-
-
r
dehydrotomatidine + NADH + H+
tomatid-4-en-3-one + NAD+
show the reaction diagram
-
-
-
-
?
DELTA5-3beta-hydroxysteroid + NAD+
DELTA4-3-oxosteroid + NADH + H+
show the reaction diagram
DELTA5-androstenediol + NAD+
testosterone + NADH + H+
show the reaction diagram
-
-
-
-
?
diacetyl + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
dimethyl-2-oxo-glutarate + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
epiandrosterone + NAD+
5alpha-androstan-3,17-dione + NADH + H+
show the reaction diagram
-
-
-
-
r
hexanophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
hydritantin + NADPH
?
show the reaction diagram
-
-
-
-
?
isatin + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
isolithocholic acid + NADP+
dehydrolithocholic acid + NADPH
show the reaction diagram
-
-
-
-
r
menadione + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
menadione + NADPH
menadiol + NADP+
show the reaction diagram
-
-
-
-
?
methylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
n-butyrophenone + NADPH
(S)-1-phenyl1-butanol + NADP+
show the reaction diagram
-
major product
-
-
r
phenylglyoxal + NADPH
?
show the reaction diagram
-
-
-
-
?
pregnenolone + NAD(P)+
pregn-5-en-3,20-dione + NAD(P)H + H+
show the reaction diagram
pregnenolone + NAD+
isoprogesterone + NADH + H+
show the reaction diagram
pregnenolone + NAD+
isoprogesterone + progesterone + NADH + H+
show the reaction diagram
-
about 90% odf product is isoprogesterone
-
r
pregnenolone + NAD+
pregn-5-en-3,20-dione + NADH + H+
show the reaction diagram
pregnenolone + NAD+
progesterone + NADH + H+
show the reaction diagram
progesterone + NADPH
3beta-hydroxy-4-pregnen-20-one + NADP+
show the reaction diagram
-
-
-
-
?
prostaglandin E1 + NADPH
?
show the reaction diagram
-
-
-
-
?
prostaglandin E2 + NADPH
?
show the reaction diagram
-
-
-
-
?
pyridine-4-aldehyde + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
sitosterol + NAD+
3-oxo-24-ethyl-cholest-5-ene + NADH + H+
show the reaction diagram
testosterone + NADPH + H+
3beta,17beta-dihydroxy-4-androsten + NADP+
show the reaction diagram
-
-
-
-
?
testosterone + NADPH + H+
? + NADP+
show the reaction diagram
-
-
-
-
r
tomatid-3-one + NAD+
tomatidine + NADH + H+
show the reaction diagram
-
-
-
-
?
valerophenone + NADPH
? + NADP+
show the reaction diagram
-
-
-
-
r
additional information
?
-