1.1.1.12: L-arabinitol 4-dehydrogenase
This is an abbreviated version!
For detailed information about L-arabinitol 4-dehydrogenase, go to the full flat file.
Word Map on EC 1.1.1.12
Reaction
Synonyms
ADH, dehydrogenase, L-arabinitol, HjLAD, L-arabinitol dehydrogenase, L-arabitol dehydrogenase, LAD, Lad1, LADA, More, NAD(P)+-dependent arabitol dehydrogenase, pentitol-DPN dehydrogenase, XYL2
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1.1.1.12 L-arabinitol 4-dehydrogenaseAdvanced search results
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results (Substrates Products
Substrates Products on EC 1.1.1.12 - L-arabinitol 4-dehydrogenase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
D-sorbitol + NAD+
? + NADH + H+
wild-type shows no activity on D-sorbitol, whereas mutant Y318F does
-
-
?
L-arabinitol + NADP+
L-xylulose + NADPH + H+
no activity with cofactor NADP+ for wild-type
-
-
?
xylitol + NADP+
D-xylulose + NADPH + H+
very low activity with NADP+
-
-
r
L-arabinitol + NAD+
L-xylulose + NADH
-
-
-
?
L-arabinitol + NAD+
L-xylulose + NADH + H+
-
enzyme of the L-arabinose catabolic pathway
-
-
r
L-arabinitol + NAD+
L-xylulose + NADH + H+
-
L-arabitol consumption rate by resting cells is of the same order of magnitude as the LAD activity determined for crude cell extracts. The strong accumulation of L-arabitol (intracellular concentration of up to 0.4 M) during aerobic L-arabinose metabolism indicates the existence of a bottleneck at the level of LAD
-
-
?
L-arabinitol + NAD+
L-xylulose + NADH + H+
-
L-arabitol consumption rate by resting cells is of the same order of magnitude as the LAD activity determined for crude cell extracts. The strong accumulation of L-arabitol (intracellular concentration of up to 0.4 M) during aerobic L-arabinose metabolism indicates the existence of a bottleneck at the level of LAD
-
-
?
L-arabitol + NAD+
L-xylulose + NADH + H+
about 20% activity compared to xylitol
-
-
r
xylitol + NAD+
D-xylulose + NADH + H+
preferred substrates, reaction of EC 1.1.1.9
-
-
r
additional information
?
-
Y318 of LadA contributes significantly to the substrate specificity difference between LAD and xylitol dehydrogenase/D-sorbitol dehydrogenase
-
-
?
additional information
?
-
-
Y318 of LadA contributes significantly to the substrate specificity difference between LAD and xylitol dehydrogenase/D-sorbitol dehydrogenase
-
-
?
additional information
?
-
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol (cf. EC 1.1.1.56), and L-arabitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol
-
-
?
additional information
?
-
-
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol (cf. EC 1.1.1.56), and L-arabitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol
-
-
?
additional information
?
-
the enzyme has L-arabitol dehydrogenase (LAD) activity and also exhibits broad specificity to polyols, such as xylitol, D-sorbitol, and ribitol. Xylitol is the preferred substrate (EC 1.1.1.9)
-
-
-
additional information
?
-
-
the enzyme has L-arabitol dehydrogenase (LAD) activity and also exhibits broad specificity to polyols, such as xylitol, D-sorbitol, and ribitol. Xylitol is the preferred substrate (EC 1.1.1.9)
-
-
-
additional information
?
-
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol (cf. EC 1.1.1.56), and L-arabitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol
-
-
?
additional information
?
-
-
the enzyme exhibits broad specificity to polyols, such as xylitol, D-sorbitol, ribitol (cf. EC 1.1.1.56), and L-arabitol. Xylitol is the preferred substrate, but native and recombinant enzyme McXDH exhibits relative activities toward L-arabinitol of approximately 20% that toward xylitol
-
-
?
additional information
?
-
-
no substrate: D-mannitol, D-arabinitol, D-sorbitol
-
-
?
additional information
?
-
no substrate: D-arabinitol. The promiscuity of LAD towards different substrates is restricted to five-carbon sugars, and no activity is observed towards either D-sorbitol or D-mannitol
-
-
?
additional information
?
-
-
no substrate: D-arabinitol. The promiscuity of LAD towards different substrates is restricted to five-carbon sugars, and no activity is observed towards either D-sorbitol or D-mannitol
-
-
?
additional information
?
-
-
enzyme contributes to 30% of total xylitol dehydrogenase activity, enzyme can partially compensate for loss of xylitol dehydrogenase function
-
-
?
