1.1.1.103: L-threonine 3-dehydrogenase
This is an abbreviated version!
For detailed information about L-threonine 3-dehydrogenase, go to the full flat file.
Reaction
Synonyms
CLOST_1621, L-ThrDH, L-threonine dehydrogenase, More, orf382, TDG, TDH, Thr dehydrogenase, ThrDH, threonine 3-dehydrogenase, threonine dehydrogenase
ECTree
Advanced search results
Reaction
Reaction on EC 1.1.1.103 - L-threonine 3-dehydrogenase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
it is suggested that the unstable L-2-amino-3-oxobutanoate spontaneousely decarboxylates to the stable aminoacetone, there is also some evidence that L-threonine is oxidatively decarboxylated by threonine dehydrogenase to produce aminoacetone
-
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
ordered bi-bi mechanism, NAD+ binds prior to L-threonine
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
His94 is an active site residue, substrate binding involved residues Gly66, Gly71, Gly77, and Val80
-
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
reaction mechanism, random bi bi kinetic mechanism
-
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
catalytic mechanism, the carboxyl group of Glu152 is important for expressing the catalytic activity, the proton relay system works as a catalytic mechanism of TDH
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
reaction mechanism involving catalytic residues T112, Y137, and K141, overview
-
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
ordered bi-bi mechanism, NAD+ binds prior to L-threonine
-
-
L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+
reaction mechanism, random bi bi kinetic mechanism
-
-