1.1.1.10: L-xylulose reductase
This is an abbreviated version!
For detailed information about L-xylulose reductase, go to the full flat file.
Word Map on EC 1.1.1.10
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1.1.1.10
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stipitis
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candida
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pichia
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biomass
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pentose
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xylulokinase
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lignocellulosic
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d-xylose
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xylose-fermenting
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hydrolysate
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nadph-dependent
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tenuis
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xylose-utilizing
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scheffersomyces
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l-arabinose
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hemicellulosic
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aldo-keto
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bioethanol
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guilliermondii
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aldose
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tropicalis
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shehatae
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oxygen-limited
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kluyveromyces
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transaldolase
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furfural
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tannophilus
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pachysolen
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bagasse
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nadph-preferring
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reesei
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marxianus
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co-fermentation
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1.1.1.21
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xylose-assimilating
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debaryomyces
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arabitol
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pharmacology
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synthesis
- 1.1.1.10
- stipitis
- candida
- pichia
- biomass
- pentose
- xylulokinase
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lignocellulosic
- d-xylose
-
xylose-fermenting
- hydrolysate
-
nadph-dependent
- tenuis
-
xylose-utilizing
- scheffersomyces
- l-arabinose
-
hemicellulosic
-
aldo-keto
-
bioethanol
- guilliermondii
- aldose
- tropicalis
- shehatae
-
oxygen-limited
- kluyveromyces
- transaldolase
- furfural
- tannophilus
- pachysolen
- bagasse
-
nadph-preferring
- reesei
- marxianus
-
co-fermentation
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1.1.1.21
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xylose-assimilating
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debaryomyces
- arabitol
- pharmacology
- synthesis
Reaction
Synonyms
DCXR, dicarbonyl/L-xylulose reductase, L-xylulose reductase, LXR, LXR3, More, NAD(P)H-dependent xylose reductase, NADP(+)-dependent xylitol dehydrogenase, NADP(H)-preferring xylitol dehydrogenase, NADP+-dependent xylitol dehydrogenase, NADP+-linked xylitol dehydrogenase, P31h, P34H, reductase, L-xylulose, RpLXR, Rplxr3, XDH, XR, XylB, xylitol dehydrogenase, xylose reductase
ECTree
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Inhibitors
Inhibitors on EC 1.1.1.10 - L-xylulose reductase
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4-methylthiophene-2-carboxylic acid N'-(2,3,3-trichloroacryloyl)-hydrazide
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IC50: 0.0003 mM for wild-type enzyme, 0.00056 mM for mutant enzyme L143F, 0.002 mM for mutant enzyme H146L, 0.0002 mM for mutant enzyme W191S, 0.0022 mM for mutant enzyme W191F
cysteine
the addition of cysteine (more than 2 mM) inactivates human L-xylulose reductase and is accompanied by a 10fold decrease in catalytic efficiency, the activity of the cysteine-inactivated enzyme is not recovered by the addition of 10 mM dithiothreitol and 2-mercaptoethanol
potassium phosphate
when the purified enzyme containing 2 mM 2-mercaptoethanol is diluted with 10 mM potassium phosphate pH 7.0, its diacetyl reductase activity is gradually decreased
4-methyl-[1,2,3]-thiadiazole-5-carboxylic acid benzyloxyamide
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IC50: 0.00023 mM for wild-type enzyme, 0.0019 mM for mutant enzyme L143F, 0.0018 mM for mutant enzyme H146L, 0.0029 mM for mutant enzyme W191S, 0.00079 mM for mutant enzyme W191F
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binds to the active site of the enzyme, complex structure determination and analysis
n-butyric acid
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specific, binds to the enzyme-NADP+ complex, the mutant enzymes show altered sensitivity to inhibition, overview
additional information
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modelling of structure-based inhibitor binding into the active site
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additional information
acetic acid, threonic acid, and octanoic acid are poor inhibitors
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additional information
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acetic acid, threonic acid, and octanoic acid are poor inhibitors
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additional information
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the level of xylose reductase decreases when the initial xylose concentration is increased from 30 to 70 g/l
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additional information
acetic acid, acetoacetic acid, 3-OH-butyric acid, and octanoic acid are poor inhibitors
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additional information
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acetic acid, acetoacetic acid, 3-OH-butyric acid, and octanoic acid are poor inhibitors
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additional information
acetic acid, oxaloacetic acid, and octanoic acid are poor inhibitors
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