Reaction catalyzed by 5-hydroxydodecatetraenal polyketide synthase (2.3.1.281)
6
+
5
NADPH
+
NADH
+
6
=
+
6
CoA
+
5
NADP+
+
NAD+
+
6
+
4
H2O
6 malonyl-CoA
+
5 NADPH
+
NADH
+
6 H+
=
(2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal
+
6 CoA
+
5 NADP+
+
NAD+
+
6 CO2
+
4 H2O
