Reaction catalyzed by 8-demethyl-8-(2,3-dimethoxy-alpha-L-rhamnosyl)tetracenomycin-C 4'-O-methyltransferase (2.1.1.307)

		+			=			+
	S-adenosyl-L-methionine	+		8-demethyl-8-(2,3-di-O-methyl-alpha-L-rhamnosyl)tetracenomycin C	=		S-adenosyl-L-homocysteine	+		8-demethyl-8-(2,3,4-tri-O-methyl-alpha-L-rhamnosyl)tetracenomycin C