Reaction catalyzed by lipoyl synthase (2.8.1.8)
[protein]-N6-(octanoyl)-L-lysine
+
an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster
+
2
+
2
+
6
=
[protein]-N6-[(R)-dihydrolipoyl]-L-lysine
+
an [Fe-S] cluster scaffold protein
+
2
sulfide
+
4
Fe3+
+
2
+
2
+
2
[protein]-N6-(octanoyl)-L-lysine
+
an [Fe-S] cluster scaffold protein carrying a [4Fe-4S]2+ cluster
+
2 S-adenosyl-L-methionine
+
2 oxidized [2Fe-2S] ferredoxin
+
6 H+
=
[protein]-N6-[(R)-dihydrolipoyl]-L-lysine
+
an [Fe-S] cluster scaffold protein
+
2 sulfide
+
4 Fe3+
+
2 L-methionine
+
2 5'-deoxyadenosine
+
2 reduced [2Fe-2S] ferredoxin
