Reaction catalyzed by methylenetetrahydrofolate dehydrogenase (NADP+) (1.5.1.5), methylenetetrahydrofolate dehydrogenase (NAD+) (1.5.1.15)
+
NADP+
=
+
NADPH
+
5,10-methylenetetrahydropteroylpentaglutamate
+
NADP+
=
5,10-methenyltetrahydropteroylpentaglutamate
+
NADPH
+
H+
