Reaction catalyzed by RCR-type E3 ubiquitin transferase (2.3.2.33)

	[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine	+		[F-box protein FBXW7]-L-threonine	=		[E2 ubiquitin-conjugating enzyme]-L-cysteine	+		[F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine
	[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine	+		[F-box protein FBXW7]-L-threonine	=		[E2 ubiquitin-conjugating enzyme]-L-cysteine	+		[F-box protein FBXW7]-3-O-ubiquitinyl-L-threonine