Reaction catalyzed by 6-deoxyerythronolide-B synthase (2.3.1.94)
+
5
+
+
6
NADPH
+
6
=
+
7
CoA
+
6
+
H2O
+
6
NADP+
propanoyl-CoA
+
5 (2S)-methylmalonyl-CoA
+
(2S)-ethylmalonyl-CoA
+
6 NADPH
+
6 H+
=
8-ethyl-8-desmethyl-6-deoxyerythronolide B
+
7 CoA
+
6 CO2
+
H2O
+
6 NADP+
