Reaction catalyzed by RING-type E3 ubiquitin transferase (2.3.2.27)

	S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine	+		[RNF186]-L-lysine	=		[E2 ubiquitin-conjugating enzyme]-L-cysteine	+		N6-(ubiquitin)n-[RNF186]-L-lysine
	S-(ubiquitin)n-[E2 ubiquitin-conjugating enzyme]-L-cysteine	+		[RNF186]-L-lysine	=		[E2 ubiquitin-conjugating enzyme]-L-cysteine	+		N6-(ubiquitin)n-[RNF186]-L-lysine