Reaction catalyzed by penicillin amidase (3.5.1.11)

		+		H2O	=			+
	cefamandole	+		H2O	=		(6R,7R)-7-amino-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid	+		(2R)-hydroxy(phenyl)acetic acid