Reaction catalyzed by hydroperoxy icosatetraenoate dehydratase (4.2.1.152)
=
+
(12R)-hydroperoxyeicosatetraenoic acid
=
(8R)-hydroxy-(11R,12R)-epoxyeicosa-(5Z,9E,14Z)-trienoic acid
+
12-oxoeicosatetraenoic acid