Reaction catalyzed by phosphatidylinositol-4,5-bisphosphate 4-phosphatase (3.1.3.78)

		+		H2O	=			+
	phosphatidylinositol 3,4,5-trisphosphate	+		H2O	=		phosphatidylinositol 3,5-bisphosphate	+		phosphate