Reaction catalyzed by glutathionylspermidine synthase (6.3.1.8), trypanothione synthase (6.3.1.9)
2
+
+
2
ATP
=
+
2
ADP
+
2
2 glutathione
+
spermidine
+
2 ATP
=
N1,N8-bis(glutathionyl)spermidine
+
2 ADP
+
2 phosphate