Reaction catalyzed by phosphatidylinositol-4,5-bisphosphate 3-kinase (2.7.1.153)

	ATP	+			=		ADP	+
	ATP	+		1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	=		ADP	+		1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate