Reaction catalyzed by methylenetetrahydrofolate reductase [NAD(P)H] (1.5.1.20)
+
NAD(P)+
=
+
NAD(P)H
+
5-methyltetrahydrofolate
+
NAD(P)+
=
5,10-methylenetetrahydrofolate
+
NAD(P)H
+
H+
