Reaction catalyzed by palmitoyl-CoA hydrolase (3.1.2.2), (S)-methylmalonyl-CoA hydrolase (3.1.2.17), ADP-dependent short-chain-acyl-CoA hydrolase (3.1.2.18), ADP-dependent medium-chain-acyl-CoA hydrolase (3.1.2.19)

		+		H2O	=			+		CoA
	malonyl-CoA	+		H2O	=		malonate	+		CoA