Reaction catalyzed by pyruvate dehydrogenase system (1.2.1.104), pyruvate dehydrogenase (acetyl-transferring) (1.2.4.1)

		+			=			+
	pyruvate	+		[dihydrolipoyllysine-residue acetyltransferase] lipoyllysine	=		[dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine	+		CO2