Reaction catalyzed by 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (1.1.1.312)
+
NADP+
=
+
NADPH
+
4-carboxy-2-hydroxymuconate semialdehyde hemiacetal
+
NADP+
=
2-oxo-2H-pyran-4,6-dicarboxylate
+
NADPH
+
H+