Reaction catalyzed by phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase (3.1.3.67)

		+		H2O	=			+
	1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate	+		H2O	=		1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate	+		phosphate