Reaction catalyzed by 15-hydroxyprostaglandin-D dehydrogenase (NADP+) (1.1.1.196), 15-hydroxyprostaglandin-I dehydrogenase (NADP+) (1.1.1.231), 13,14-dehydro-15-oxoprostaglandin 13-reductase (1.3.1.48)
+
NADP+
=
+
NADPH
+
prostaglandin E2
+
NADP+
=
15-ketoprostaglandin E2
+
NADPH
+
H+
