Reaction catalyzed by 12alpha-hydroxysteroid dehydrogenase (1.1.1.176)

		+		NAD(P)+	=			+		NAD(P)H
	cholic acid	+		NAD(P)+	=		3alpha,7alpha-dihydroxy-12-oxo-5beta-cholan-24-oic acid	+		NAD(P)H