Reaction catalyzed by 11beta-hydroxysteroid dehydrogenase (1.1.1.146)

		+		NADPH	=			+		NADP+
	17alpha,21-dihydroxypregna-1,4-diene-3,11,20-trione	+		NADPH	=		11beta,17alpha,21-trihydroxypregna-1,4-diene-3,20-dione	+		NADP+